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Antioxidant and Anti-inflammatory Effects of Yogurt Enriched With Polyphenols

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02494739
Recruitment Status : Completed
First Posted : July 10, 2015
Last Update Posted : February 2, 2016
Sponsor:
Information provided by (Responsible Party):
Athanasios Z. Jamurtas, University of Thessaly

Brief Summary:
The purpose of this study is to investigate the possible antioxidant and anti-inflammatory effects of yogurt enriched with polyphenols after 2-week consumption by healthy individuals.

Condition or disease Intervention/treatment Phase
Oxidative Stress Inflammation Other: Yogurt enriched with polyphenols Other: Yogurt not enriched with polyphenols Not Applicable

Detailed Description:
Eighteen healthy adult volunteers of both sexes consumed yogurt (400g per day) enriched with polyphenols (10mg/100g yogurt) or yogurt (400g per day) not enriched with polyphenols for two weeks in a double-blind, crossover, randomized manner.There was a washout period of at least 10 days. Physiological data and blood samples were collected before and after consumption of each yogurt.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 18 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Basic Science
Official Title: Investigation of the Antioxidant and Anti-inflammatory Effects of Yogurt Enriched With Polyphenols
Study Start Date : May 2015
Actual Primary Completion Date : June 2015
Actual Study Completion Date : June 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Antioxidants

Arm Intervention/treatment
Experimental: Yogurt enriched with polyphenols
Two yogurts (400g) enriched with polyphenols (10mg/100g yogurt) per day, for two weeks.
Other: Yogurt enriched with polyphenols
Yogurt enriched with polyphenols extracted from grape seeds

Placebo Comparator: Yogurt not enriched with polyphenols
Two yogurts (400g) not enriched with polyphenols per day, for two weeks.
Other: Yogurt not enriched with polyphenols
Yogurt not enriched with polyphenols




Primary Outcome Measures :
  1. Antioxidant effects [ Time Frame: Two weeks ]
    Indices of blood antioxidant status

  2. Anti-inflammatory effects [ Time Frame: Two weeks ]
    Indices of inflammation in blood


Secondary Outcome Measures :
  1. Body composition [ Time Frame: Two weeks ]
    Body fat percentage

  2. Blood pressure [ Time Frame: Two weeks ]
    Blood pressure at rest

  3. Hydration [ Time Frame: Two weeks ]
    Urine specific gravity

  4. Resting heart rate [ Time Frame: Two weeks ]
    Resting heart rate

  5. Blood glucose levels [ Time Frame: Two weeks ]
  6. Triglyceride levels [ Time Frame: Two weeks ]
  7. Total cholesterol levels [ Time Frame: Two weeks ]
  8. High Density Lipoprotein cholesterol levels [ Time Frame: Two weeks ]


Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy individuals
  • Non-smokers

Exclusion Criteria:

  • Current use of dietary supplements or drugs
  • Metabolic disease
  • Lactose intolerance
  • Pregnant, pregnancy intention or breast feeding

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02494739


Locations
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Greece
Department of Physical Education & Sport Science of the University of Thessaly
Trikala, Karyes, Greece, 42100
Sponsors and Collaborators
University of Thessaly
Investigators
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Study Director: Athanasios Z Jamurtas, PhD University of Thessaly

Publications:
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Responsible Party: Athanasios Z. Jamurtas, Associate Professor, University of Thessaly
ClinicalTrials.gov Identifier: NCT02494739    
Other Study ID Numbers: UniYog-2015x
First Posted: July 10, 2015    Key Record Dates
Last Update Posted: February 2, 2016
Last Verified: January 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Keywords provided by Athanasios Z. Jamurtas, University of Thessaly:
antioxidant
oxidative stress
inflammation
polyphenols
yogurt
Additional relevant MeSH terms:
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Inflammation
Pathologic Processes
Anti-Inflammatory Agents
Antioxidants
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs