Comparison Between Clinical and MRI Multiple Sclerosis Activity and Expression of Human Endogenous Retrovirus Type W and Herpesvirus
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|ClinicalTrials.gov Identifier: NCT02489877|
Recruitment Status : Unknown
Verified July 2015 by Guilherme Sciascia do Olival, Faculdade de Ciências Médicas da Santa Casa de São Paulo.
Recruitment status was: Not yet recruiting
First Posted : July 3, 2015
Last Update Posted : July 3, 2015
Faculdade de Ciências Médicas da Santa Casa de São Paulo
University of Sao Paulo
Information provided by (Responsible Party):
Guilherme Sciascia do Olival, Faculdade de Ciências Médicas da Santa Casa de São Paulo
Multiple sclerosis is the most common autoimmune inflammatory disease of the central nervous system. It is known that your etiology has genetic and environmental causes. Several viruses have been implicated as triggers as well as perpetrators of this disease. Several studies make the correlation between Endogenous Retrovirus Type W (HERV-W) and the family Herpesviridae and activity in the pathogenesis of multiple sclerosis. The most important characteristics of the virus implicated in the pathogenesis of the disease is the fact that they have latency periods of exacerbation and they have, as their main biological environment, the central nervous system. The HERV-W, Epstein-Barr virus (EBV), cytomegalovirus, herpes virus type 6 and type 7 herpesvirus members are the most studied as causes of multiple sclerosis. It was found that these viruses are closely involved in the pathogenesis of MS, but it is believed that aren't the only responsible for its beginning. It is likely that this disease presents numerous triggers and more studies are needed to determine these interactions. In addition, a study comparing the activity of multiple sclerosis with the presence of these viruses was never realized.
|Condition or disease|
Show Detailed Description
|Study Type :||Observational|
|Estimated Enrollment :||84 participants|
|Observational Model:||Case Control|
|Official Title:||Comparison Between Clinical and MRI Multiple Sclerosis Activity and Expression of Human Endogenous Retrovirus Type W and Herpesvirus in Peripheral Blood of Patients|
|Study Start Date :||July 2015|
|Estimated Primary Completion Date :||July 2016|
|Estimated Study Completion Date :||July 2017|
Patients diagnosed with Multiple Sclerosis
without Multiple Sclerosis
Healthy individuals without neurological disease associated
with other neurological diseases
Patients diagnosed with the following diseases: Lateral Amniotrofic Sclerosis, Headache , Parkinson's disease, Dementia and Epilepsy.
Primary Outcome Measures :
- Composite: Degree of disease activity [ Time Frame: 1 year ]The degree of disease activity will be a composite of clinical and imaging measures. Clinical measures will be analyzed by annualized rate of relapses and EDSS-scale increase. The imaging measures will be analyzed by increase cranial lesions on MRI. This date will be correlated with quantitative assessment of HERV-W and viruses of the Herpesviridae family.
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