ClinicalTrials.gov
ClinicalTrials.gov Menu

the Influence of General Anesthesia on Tumor Metastasis and Recurrence

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT02474511
Recruitment Status : Recruiting
First Posted : June 17, 2015
Last Update Posted : June 17, 2015
Sponsor:
Information provided by (Responsible Party):
RenJi Hospital

Brief Summary:
The purpose of this study was to investigate whether general anesthesia will affect the postoperative recurrence and metastasis of malignant tumor.

Condition or disease Intervention/treatment
Tumor Recurrence and Metastasis Other: general anesthesia and local anesthesia

Study Type : Observational
Estimated Enrollment : 300 participants
Observational Model: Cohort
Time Perspective: Prospective
Study Start Date : June 2015
Estimated Primary Completion Date : June 2018
Estimated Study Completion Date : April 2019

Group/Cohort Intervention/treatment
general anesthesia
In this group,the patient is received radiofrequency ablation under general anesthesia.
Other: general anesthesia and local anesthesia
the patient received generalanesthesia and local anesthesia randomly

local anesthesia
In this group,the patient is received radiofrequency ablation under local anesthesia.
Other: general anesthesia and local anesthesia
the patient received generalanesthesia and local anesthesia randomly




Primary Outcome Measures :
  1. Number of participants with tumor recurrence and metastasis [ Time Frame: 3 years ]
    Follow-up of patients with tumor recurrence and metastasis after Radiofrequency ablation to 3 years


Biospecimen Retention:   Samples Without DNA
blood


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
the patient with primary liver cancer.
Criteria

Inclusion Criteria:

  • ASA I - III Primary liver cancer tumor is single and diameter is less than 3 centimeter There is no major vascular invasion phenomenon, no lymph nodes or extrahepatic metastases The Child - Pugh belong to type A or type B

Exclusion Criteria:

  • Had a history of liver surgery (including radiofrequency ablation) Severe disease of heart, lung, kidney, the immune system INR > 1.5 or platelet count is less than 45000 cells/mm3 History of opioid addiction Metastatic liver tumors Not sure of primary liver cancer Don't agree to participate in this experiment

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02474511


Locations
China, Shanghai
Shanghai Renji Hospital Recruiting
Shanghai, Shanghai, China, 200127
Contact: diansan su, Ph.D    18616514088    diansansu@yahoo.com   
Sponsors and Collaborators
RenJi Hospital

Responsible Party: RenJi Hospital
ClinicalTrials.gov Identifier: NCT02474511     History of Changes
Other Study ID Numbers: 仁济伦审[2015]058K
First Posted: June 17, 2015    Key Record Dates
Last Update Posted: June 17, 2015
Last Verified: June 2015

Additional relevant MeSH terms:
Neoplasm Metastasis
Recurrence
Neoplastic Processes
Neoplasms
Pathologic Processes
Disease Attributes
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs