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Trial record 19 of 312 for:    "Periodontitis, Chronic"

Gene Expression Profiles in Chronic Periodontitis

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ClinicalTrials.gov Identifier: NCT02467283
Recruitment Status : Completed
First Posted : June 10, 2015
Last Update Posted : February 12, 2018
Sponsor:
Information provided by (Responsible Party):
Esra Guzeldemir-Akcakanat, Kocaeli University

Brief Summary:

Current concepts of the causes of periodontitis implicate a bacterial infection as the primary cause of the disease. Several bacterial species residing in a biofilm on tooth surfaces are closely associated with periodontitis. Chronic periodontitis (CP) is initiated and sustained by bacterial plaque, but host defense mechanisms play an integral role in its pathogenesis.

Gene expression profiling is a powerful means of generating comprehensive genome-level data sets on diseases such as cancer, asthma, rheumatoid disorders and periodontitis, and provides significant insight information for these diseases. Gene expression profiling may provide an evidence for involving genes in the pathogenesis of CP and generate further information other than clinical signs and symptoms of CP.

The aim of this study was to identify gene-expression patterns of patients with chronic periodontitis by whole-transcriptome gene-expression analyses.


Condition or disease Intervention/treatment
Chronic Periodontitis Genetic: Genom-based whole-genome transcriptomic

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Study Type : Observational
Actual Enrollment : 46 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Gene Expression Profiles in Chronic Periodontitis: A Gene Network-based Microarray Analysis
Actual Study Start Date : February 2013
Actual Primary Completion Date : August 2015
Actual Study Completion Date : May 2017

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
Patients with Chronic Periodontitis

All subjects were free of systemic diseases and to be included, individuals had to be older than 18 years of age.

Chronic periodontitis was diagnosed according to American Academy of Periodontology 1999 Consensus Report.

Genetic: Genom-based whole-genome transcriptomic
Gene expression profiling is a powerful means of generating comprehensive genome-level data sets.

Control Patients

Control subjects had no radiographic evidence of bone loss or any sign of past and present periodontitis.

All subjects were free of systemic diseases and to be included, individuals had to be older than 18 years of age.

Genetic: Genom-based whole-genome transcriptomic
Gene expression profiling is a powerful means of generating comprehensive genome-level data sets.




Primary Outcome Measures :
  1. mRNA quantification [ Time Frame: 2 months ]

Secondary Outcome Measures :
  1. Gen networking map [ Time Frame: 2 months ]


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
The patientswere recruited from those patients seeking dental treatment in Kocaeli University, Faculty of Dentistry Periodontology Clinics.
Criteria

Inclusion Criteria:

  1. CP patients had at least 20 teeth exhibiting >30% of measured sites with >5mm clinical attachment loss.
  2. Had bleeding on probing (BOP) at >50% of the proximal sites.

Exclusion Criteria:

  1. Had any known systemic diseases that can influence the periodontal status, oral diseases other than chronic periodontitis and ongoing orthodontic therapy.
  2. History of hepatitis, HIV infection, or diabetes; requirement for antibiotic prophylaxis, pregnancy or lactation; and long-term use of anti-inflammatory drugs.
  3. Should be free of systemic diseases
  4. Individuals had to be older than 18 years of age.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02467283


Sponsors and Collaborators
Kocaeli University
Investigators
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Principal Investigator: Esra Guzeldemir-Akcakanat, DDS, PhD Chair and Associate Professor of Dept. of Periodontology

Publications:
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Responsible Party: Esra Guzeldemir-Akcakanat, Associate Profesor, Kocaeli University
ClinicalTrials.gov Identifier: NCT02467283     History of Changes
Other Study ID Numbers: KOU KAEK 2013 / 15
First Posted: June 10, 2015    Key Record Dates
Last Update Posted: February 12, 2018
Last Verified: February 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Keywords provided by Esra Guzeldemir-Akcakanat, Kocaeli University:
chronic periodontitis
genetics
microarray analysis
gingiva
genes
inflammation

Additional relevant MeSH terms:
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Periodontitis
Chronic Periodontitis
Periodontal Diseases
Mouth Diseases
Stomatognathic Diseases