Examination of Biopsies From Healthy Knee Joints
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|ClinicalTrials.gov Identifier: NCT02458170|
Recruitment Status : Terminated (Shutdown of The Department of Inflammatory Diseases at Novo Nordisk.)
First Posted : June 1, 2015
Last Update Posted : June 1, 2015
|Condition or disease|
|Abnormality in Synovial Tissue|
Arthritis is caused by autoimmune disease in the cells and pathogenesis of the tissue. This autoimmune inflammation is very often a chronic disease which causes irreversible articular damage. Rheumatoid arthritis is very often a painful and disabling disease if the treatment turns out to be ineffectual. Several of the available remedies can not treat the disease totally but only keep the patients in check.
The biological mechanisms which cause an autoimmune inflammatory articular disease have not been proved scientifically yet. Under normal conditions, the immune system adapts easily in order to protect the body against pathogenic bacteria and virus without causing damage on the body's own cells. Autoimmune inflammatory diseases displace this balance in a way so that the immune system can not distinguish between "self" and "non-self". Different kinds of cells are involved in this chronic inflammation in the joints. Majority of these cells belong to the heart of the immune response, for example T-lymphocytes, B-lymphocytes, macrophages, dendrites and granulocytes. However, other cells are also involved, for example synovial fibroblasts and endothelium.
It is very important to understand the interaction of these cells in order to develop new medicinal products for inflammatory articular diseases. The big challenge for conduction research in inflammatory articular diseases is to achieve more evidence-based knowledge of the synovial tissue from the patients and the control group.
|Study Type :||Observational|
|Actual Enrollment :||43 participants|
|Official Title:||Examination of Biopsies From Healthy Knee Joints for the Use of Research Activities in Inflammatory Joint Diseases|
|Study Start Date :||August 2013|
|Actual Primary Completion Date :||December 2014|
|Actual Study Completion Date :||December 2014|
- Adverse events as a measure of metabolism in normal tissue and inflammatory tissue. [ Time Frame: 7 years ]Compare the normal metabolism in non-inflammatory tissue with biopsies of inflammatory diseases.
- Detect new objects for developing drugs. [ Time Frame: 7 years ]Determine potential objects for medical intervention and development of drugs which affect the molecular mechanisms in relation to an inflammatory condition versus a normal metabolic condition.
Biospecimen Retention: Samples With DNA
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02458170
|Northern Orthopaedic Division, Aalborg University Hospital|
|Aalborg, Denmark, DK-9000|
|Study Chair:||Sten Rasmussen, M.D.||Northern Orthopaedic Division, Aalborg University Hospital|