XNKQ Acupuncture Compared to Control Interventions Measured With EEG and fMRI
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ClinicalTrials.gov Identifier: NCT02453906 |
Recruitment Status :
Completed
First Posted : May 27, 2015
Last Update Posted : July 27, 2016
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Stroke | Other: XNKQ Other: Control 1 Other: Control 2 Other: Control 3 | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 29 participants |
Allocation: | Randomized |
Intervention Model: | Factorial Assignment |
Masking: | Single (Participant) |
Primary Purpose: | Basic Science |
Official Title: | Cerebral Response of Healthy Subjects to a Somatosensory Stimulation With XNKQ Acupuncture Compared to Control Interventions Measured With EEG and fMRI |
Study Start Date : | May 2015 |
Actual Primary Completion Date : | September 2015 |
Actual Study Completion Date : | September 2015 |
Arm | Intervention/treatment |
---|---|
Experimental: healthy subjects
they receive XNKQ acupuncture, as well as control 1, control 2, and control 3 in a randomized order.
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Other: XNKQ
stimulation at 5 acupuncture points according to XNKQ acupuncture Other: Control 1 no stimulation at 5 acupuncture points according to XNKQ acupuncture Other: Control 2 stimulation at 5 control points Other: Control 3 no stimulation at 5 control points |
- Change in brain background rhythms (mu-alpha and beta activity) [assessed using EEG and MRI] after one intervention (baseline vs. post stimulation) in comparison between the four different interventions. [ Time Frame: 60 minutes ]
- Changes in resting state functional connectivity [assessed using EEG and MRI] after one intervention (baseline vs. post-stimulation) in comparison between the four different interventions [ Time Frame: 60 minutes ]

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Ages Eligible for Study: | 18 Years to 40 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Healthy subjects (18 to 40 years of age) health status confirmed by a comprehensive neurological examination
- Right-handed (evaluated by "the Edinburgh inventory")
- Informed consent
- No acupuncture treatment in the last 12 months
- No medical knowledge about acupuncture
Exclusion Criteria:
- History of neurological and/or psychiatric diseases
- History of brain injury
- Cognitive handicap and severe speech disorder
- alcohol or drug abuse
- History of neurosurgical intervention
- Chronic disease (e.g., asthma, diabetes mellitus etc.) with regular use of medications
- Usage of acute medication
- Pregnancy (tested by urine pregnancy test before the measurement) or planned pregnancy
- Any contraindication for acupuncture (e.g., anti-coagulation therapy)
- Any exclusion criteria for MRI scanning (metal implants (e.g. pacemaker), claustrophobia, etc.)
- Participation in another interventional trial.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02453906
Germany | |
Charité - Universitätsmedizin Berlin | |
Berlin, Germany |
Principal Investigator: | Claudia M. Witt, MD | Charite University, Berlin, Germany |
Responsible Party: | Claudia M. Witt, Professor, Charite University, Berlin, Germany |
ClinicalTrials.gov Identifier: | NCT02453906 |
Other Study ID Numbers: |
XNKQ-15 |
First Posted: | May 27, 2015 Key Record Dates |
Last Update Posted: | July 27, 2016 |
Last Verified: | July 2016 |