Acute Vascular Response to Exercise in Women With Nonobstructive Coronary Artery Disease
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|ClinicalTrials.gov Identifier: NCT02450318|
Recruitment Status : Recruiting
First Posted : May 21, 2015
Last Update Posted : August 13, 2021
|Condition or disease||Intervention/treatment||Phase|
|Nonobstructive Coronary Artery Disease||Other: Slow-paced walking||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||75 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Acute Vascular Response to Exercise in Women With Nonobstructive Coronary Artery Disease|
|Actual Study Start Date :||June 2015|
|Estimated Primary Completion Date :||May 2022|
|Estimated Study Completion Date :||May 2022|
Experimental: Slow-paced walking
Subjects will complete 47 minutes of walking at slow pace.
Other: Slow-paced walking
Subjects will walk on a treadmill at a slow pace for 47 minutes
- Change in endothelium-dependent dilation [ Time Frame: Baseline, 15 minutes after exercise and 1 hour after exercise ]Brachial artery endothelium-dependent flow-mediated dilation to reactive hyperemia will be measured using high resolution ultrasonography. To determine flow-mediated dilation, brachial artery diameter and blood velocity will be measured before and after occluding the forearm for 5 minutes by inflating a cuff to 250 mmHg.
- Change in endothelium-independent dilation [ Time Frame: Baseline, 15 minutes after exercise ]To determine vascular smooth muscle responsiveness to nitric oxide, brachial artery diameter will be measured using high resolution ultrasonography before and after sublingual administration of 0.4mg nitroglycerin.
- Change in arterial stiffness and wave reflection [ Time Frame: Baseline, 15 minutes after exercise and 1 hour after exercise ]Aortic pulse wave velocity and augmentation index will be measured using applanation tonometry.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02450318
|Contact: Demetra Christou, PhD||352-294-1746||ICPL@hhp.ufl.edu|
|Contact: Eileen Handbergfirstname.lastname@example.org|
|United States, Florida|
|Integrative Cardiovasculal Physiology Laboratory||Recruiting|
|Gainesville, Florida, United States, 32611|
|Contact: Demetra Christou, PhD 352-294-1746 ICPL@hhp.ufl.edu|
|Principal Investigator:||Demetra Christou, PhD||University of Florida|