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Hemodynamic Changes After Anesthesia With Propofol: Study of Biomarkers

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ClinicalTrials.gov Identifier: NCT02442232
Recruitment Status : Completed
First Posted : May 13, 2015
Last Update Posted : August 26, 2016
Sponsor:
Information provided by (Responsible Party):
Gustavo Henrique Oliveira de Paula, University of Sao Paulo

Brief Summary:
The purpose of this study is to evaluate biomarkers affecting the hemodynamic responses to propofol. Particularly, the investigators will assess the effects of polymorphisms in NOS3 and PRKCA genes on hemodynamic responses to propofol and the effects of these polymorphisms on biomarkers related to nitric oxide after propofol anesthesia. In addition, the investigators will evaluate the effects of propofol anesthesia on biomarkers related to nitric oxide in hypertensive patients chronically treated with angiotensin-converting enzyme inhibitors.

Condition or disease
Hemodynamic Responses to Propofol

Study Type : Observational
Actual Enrollment : 65 participants
Observational Model: Case Control
Time Perspective: Prospective
Study Start Date : August 2015
Actual Primary Completion Date : December 2015
Actual Study Completion Date : May 2016

Group/Cohort
Normotensive
Hypertensive taking ACEi
Hypertensive not taking ACEi



Primary Outcome Measures :
  1. Systolic blood pressure [ Time Frame: 10 minutes ]
  2. Diastolic blood pressure [ Time Frame: 10 minutes ]
  3. Mean blood pressure [ Time Frame: 10 minutes ]
  4. Heart rate [ Time Frame: 10 minutes ]
  5. Plasma nitrite levels [ Time Frame: 10 minutes ]
  6. Plasma nitrate levels [ Time Frame: 10 minutes ]


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Ages Eligible for Study:   40 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients under propofol anesthesia
Criteria

Inclusion Criteria:

  • ASA I or II
  • BMI lower 30 kg/m2

Exclusion Criteria:

  • Severe hypertension
  • Previous stroke
  • Previous infarction
  • Uncontrolled respiratory, renal, hepatic and hematological diseases.

Responsible Party: Gustavo Henrique Oliveira de Paula, PhD student, University of Sao Paulo
ClinicalTrials.gov Identifier: NCT02442232     History of Changes
Other Study ID Numbers: CNPq
First Posted: May 13, 2015    Key Record Dates
Last Update Posted: August 26, 2016
Last Verified: August 2016