Effects of Low Intensity Aerobic Exercise on the Microvascular Endothelial Function of Patients With Type 1 Diabetes
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02441504|
Recruitment Status : Completed
First Posted : May 12, 2015
Last Update Posted : May 13, 2015
Background: The aim of the present study was to evaluate the changes in the microvascular density and reactivity in patients with type 1 diabetes (T1D) resulting from low intensity chronic exercise training.
Methods: This study included 22 (34 ± 7 years) consecutive outpatients with T1D and disease duration > six years. We used intravital video-microscopy to measure the basal skin capillary density as well as capillary recruitment using post-occlusive reactive hyperemia (PORH) in the dorsum of the fingers. Endothelium-dependent and -independent vasodilation of the skin microcirculation was evaluated in the forearm with a laser Doppler perfusion monitoring (LDPM) system in combination with acetylcholine and sodium nitroprusside iontophoresis, PORH and local thermal hyperemia.
|Condition or disease||Intervention/treatment||Phase|
|Diabetes Mellitus, Type 1||Other: Low intensity Exercise||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||22 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Effects of Low Intensity Aerobic Exercise Training on the Microvascular Endothelial Function of Patients With Type 1 Diabetes: a Non-pharmacological Interventional Study|
|Study Start Date :||January 2014|
|Actual Primary Completion Date :||September 2014|
|Actual Study Completion Date :||October 2014|
Active Comparator: Low intensity exercise
Other: Low intensity Exercise
aerobic exercise training using walking and running
- Change in Cutaneous Capillary Density in twelve weeks of aerobic physical activity [ Time Frame: before and after 12 weeks of aerobic physical activity ]Chronic aerobic exercise has been involved in angiogenic processes that result in increased perfusion and capillary density. We believe that 12 weeks of aerobic exercise of low intensity is also able to exert the same effects in type 1diabetics patients. The microvascular cutaneous reactivity was studied by laser Doppler perfusion monitoring (LDPM), a method that has previously been standardized and validated. The capillary density, defined as the number of perfused capillaries per mm2 of skin area, was assessed by high-resolution intra-vital color microscopy using a video microscopy system with an epi-illuminated fiber optic microscope containing a 100-W mercury vapor lamp light source and an M200 objective with a final magnification of 200X.