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Nitrate for High Intensity Intermittent Exercise (NITR-ITE)

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ClinicalTrials.gov Identifier: NCT02436629
Recruitment Status : Completed
First Posted : May 7, 2015
Last Update Posted : July 6, 2016
Sponsor:
Information provided by (Responsible Party):
Maastricht University Medical Center

Brief Summary:
The objective of the current study is to assess the effect of 6-day dietary nitrate ingestion on high intensity intermittent sports performance in recreational soccer players.

Condition or disease Intervention/treatment Phase
High Intensity Intermittent Sports Performance Dietary Supplement: Nitrate-rich concentrated beetroot juice Dietary Supplement: Nitrate-depleted concentrated red beetroot juice Phase 4

Detailed Description:
Oral ingestion of nitrate (NO3-) in the form of both nitrate salts and concentrated red beetroot juice has been shown to significantly lower blood pressure at rest and to improve exercise performance during cycle time trials. Furthermore, a positive exercise performance effect of nitrate ingestion has been observed in recreational athletes during intermittent exercise. However, this was achieved after acute supplementation with a substantial dose of dietary nitrate. Whether similar ergogenic effects of nitrate supplementation can be achieved with a more conventional 6-day nitrate supplementation protocol with a lower daily dose remains to be established. Based on the gaps in current literature, our main goal will be to gain further insight into the effects of a 6-day nitrate supplementation protocol on high intensity intermittent exercise performance in recreational athletes.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: The Effect of Nitrate Supplementation on Sport Performance: High Intensity Intermittent Performance in Recreational Athletes
Study Start Date : May 2015
Actual Primary Completion Date : April 2016
Actual Study Completion Date : July 2016

Arm Intervention/treatment
Active Comparator: Nitrate-rich concentrated beetroot juice
Dietary supplement: 800 mg of nitrate in 140 mL of concentrated beetroot juice (Beet-IT)
Dietary Supplement: Nitrate-rich concentrated beetroot juice
James White, Beet It Sport Shot, 70ml (Standard)

Placebo Comparator: Nitrate-depleted conc. beetroot juice
Placebo: 140 mL of nitrate-depleted concentrated red beetroot juice
Dietary Supplement: Nitrate-depleted concentrated red beetroot juice
Beet It Sport Shot, 70ml (Placebo)




Primary Outcome Measures :
  1. Total distance covered during the Yo-Yo Intermittent Recovery 1 test (Yo-Yo IR1 test) [ Time Frame: Performance 3 hours post red beetroot juice ingestion ]

Secondary Outcome Measures :
  1. Plasma concentration of nitrite and nitrate [ Time Frame: Concetrations 3 hours post red beetroot juice ingestion ]
  2. Salivary concentration of nitrite and nitrate [ Time Frame: Concetrations 3 hours post red beetroot juice ingestion ]

Other Outcome Measures:
  1. Baseline characteristics [ Time Frame: 30 min during visit 1 (Screening) ]
    Height, body weight, age, BMI



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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy P
  • Players of the first two senior selection teams of a regional soccer club competing at the 3rd KNVB level or higher
  • Training ≥2 days a week
  • 18-40 years
  • Male

Exclusion Criteria:

  • Use of medication
  • Injury prohibiting them from performing the exercise protocol effectively
  • Smoking
  • Currently supplementing diet with nitrate
  • Lactose intolerance

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02436629


Locations
Netherlands
Maastricht University Medical Centre+
Maastricht, Limburg, Netherlands, 6200MD
Sponsors and Collaborators
Maastricht University Medical Center
Investigators
Principal Investigator: Lex B Verdijk, PhD Maastricht University