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Adult Arm of DZL All Age Asthma Cohort (ALLIANCE) (ALLIANCE)

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ClinicalTrials.gov Identifier: NCT02419274
Recruitment Status : Recruiting
First Posted : April 17, 2015
Last Update Posted : August 10, 2018
Sponsor:
Collaborators:
German Center for Lung Research
Research Center Borstel
Information provided by (Responsible Party):
LungenClinic Grosshansdorf

Brief Summary:

Deep Phenotyping of adult asthma patients:

  • severity from mild to severe
  • both atopic and non-atopic
  • both childhood and adult onset
  • both smokers and non-smokers
  • corresponding pediatric cohort (Pediatric Arm of DZL All Age Asthma Cohort) with equivalent SOPs regarding collection of biomaterial and clinical data incl. lung function, further processing of biomaterial and further analyses

Condition or disease
Asthma

Detailed Description:

The clinical heterogeneity of asthma patients has been increasingly recognised within the last years. Recent studies and articles highlighted the idea of asthma not beeing a single disease but rather a unifying term for multiple phenotypes. Phenotype in this sense is defined as the combination of observable properties of an organism, that are produced by the interactions of a genotype and the environment. In contrast, endotype describes a specific underlying pathophysiological pathway. Linking asthma phenotypes and endotypes in a system biological approach is an important research goal in order to develop targeted therapy, especially for severe asthma.

The advantage the investigators' cohort provides is the collaboration with an equivalent pediatric cohort. In this setting questions regarding disease onset, exacerbation and chronicity can be posed and worked with in a comprehensive manner.


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Study Type : Observational [Patient Registry]
Estimated Enrollment : 350 participants
Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration: 6 Years
Official Title: The All Age Asthma Cohort (ALLIANCE) of the German Center for Lung Research (DZL), Adult Arm
Study Start Date : March 2014
Estimated Primary Completion Date : October 2020
Estimated Study Completion Date : December 2020

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Asthma




Primary Outcome Measures :
  1. Defining clinical asthma phenotypes by combining clinical, lung function and biomaterial data [ Time Frame: 2 years ]

Biospecimen Retention:   Samples With DNA
Collection of blood, nasal secretions, sputum and exhaled breath, such as pharyngeal and nasopharyngeal swabs


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 99 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Asthma of all severity grades, both allergic and non-allergic. Age of Onset childhood and adulthood. Smokers and non-smokers.

Proven Asthma according to current GINA Guidelines (2014)

Healthy Control Group.

Criteria

Inclusion Criteria:

  • Proven Diagnosis according to current GINA Guideline (2014)
  • Ability to read and understand German
  • Ability to understand and agree to informed consent

Exclusion Criteria:

  • History of respiratory tract infection within the last 4 weeks before inclusion

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02419274


Contacts
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Contact: Thomas J Bahmer, MD +49 4102 601 2412 t.bahmer@lungenclinic.de
Contact: Joern Bullwinkel, PhD +49 4102 601 2410 j.bullwinkel@lungenclinic.de

Locations
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Germany
Research Center Borstel Recruiting
Borstel, Germany, 23845
Contact: Peter Zabel, MD PhD    +49 4537-188-0    pzabel@fz-borstel.de   
Contact: Karoline I Gaede, PhD    +49 4537-188-7050    kgaede@fz-borstel.de   
LungenClinic Grosshansdorf Recruiting
Grosshansdorf, Germany, 22927
Contact: Thomas J Bahmer, MD    +49-4102-601-2412    t.bahmer@lungenclinic.de   
Contact: Joern Bullwinkel, PhD    +49-4102-601-2410    j.bullwinkel@lungenclinic.de   
Sponsors and Collaborators
LungenClinic Grosshansdorf
German Center for Lung Research
Research Center Borstel
Investigators
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Principal Investigator: Klaus F Rabe, MD PhD LungenClinic Grosshansdorf, Grosshansdorf, Germany
Principal Investigator: Peter Zabel, MD PhD Research Center Borstel, Borstel, Germany

Additional Information:

Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: LungenClinic Grosshansdorf
ClinicalTrials.gov Identifier: NCT02419274     History of Changes
Other Study ID Numbers: DZL-GHD-ERA
First Posted: April 17, 2015    Key Record Dates
Last Update Posted: August 10, 2018
Last Verified: August 2018

Keywords provided by LungenClinic Grosshansdorf:
asthma
phenotype
childhood
adulthood

Additional relevant MeSH terms:
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Asthma
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases