Furosemide Stress Test as a Predictor of Tubular Function in Chronic Kidney Disease (FST-IFTA)
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|ClinicalTrials.gov Identifier: NCT02417883|
Recruitment Status : Unknown
Verified April 2015 by Magdalena Madero, Instituto Nacional de Cardiologia Ignacio Chavez.
Recruitment status was: Recruiting
First Posted : April 16, 2015
Last Update Posted : April 16, 2015
|Condition or disease||Intervention/treatment||Phase|
|Chronic Kidney Disease||Drug: Furosemide||Phase 3|
All patients scheduled for kidney biopsy will be invited to participate in a standard isovolemic furosemide stress test before the biopsy procedure. The latter will consist in 1.5 miligrams per kilogram of weight of intravenous furosemide administration, with urinary output follow up and measurement. The urinary output will be replaced intravenously with normal saline to avoid dehydration and/or hypotension. A standard 5ml sample of blood will be taken before the test and aliquots of urine before and after furosemide administration will be frozen.
After completion of the formely mentioned test, patients will proceed to their scheduled kidney biopsy along with interventions considered appropiate by their attending physician.
Kidney biopsy sample will be examined by histopathology service and the degree of interstitial fibrosis will be described. The degree of fibrosis will be correlated with the degree furosemide excretion and urinary output.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||100 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Furosemide Stress Test as a Predictor of Tubular Atrophy and Interstitial Fibrosis in Patients With Chronic Kidney Disease|
|Study Start Date :||April 2015|
|Estimated Primary Completion Date :||April 2016|
|Estimated Study Completion Date :||April 2017|
Experimental: Furosemide Stress Test
Furosemide stress test will be perform to patients scheduled for kidney bipsy. The test consist in 1.5 miligrams per kilogram of weight of intravenous furosemide administration, along with urinary output follow up and measurement for 6 hours. The urinary output will be replaced intravenously with normal saline to avoid dehydration and/or hypotension.
Evaluate urinary excretion rate fo furosemide
- Urinary Output [ Time Frame: 6 hours ]Cuantify urinary output after furosemide administration
- Furosemide excretion rate [ Time Frame: 6hrs ]Cuantify furosemide excretion in urine
- Interstitial Fibrosis [ Time Frame: 3 days ]Measure interstitial fibrosis in kidney biopsy
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02417883
|Contact: Magdalena Madero, MD||+55-5573-2911 ext firstname.lastname@example.org|
|Contact: Carlos A Garza, MD||+55-5573-2911 ext email@example.com|
|Instituto Nacional de Cardiologia Ignacio Chavez||Recruiting|
|Mexico city, DF, Mexico, 14080|
|Contact: Magdalena Madero, MD firstname.lastname@example.org|
|Principal Investigator:||Magdalena Madero, MD||Chief of the Nephrology Department|