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Vitamin D Status and Immune Function

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ClinicalTrials.gov Identifier: NCT02416895
Recruitment Status : Completed
First Posted : April 15, 2015
Last Update Posted : April 5, 2017
Sponsor:
Collaborator:
University of East Anglia
Information provided by (Responsible Party):
Bangor University

Brief Summary:
The purpose of this study is to examine the relationship between Vitamin D status and immunity.

Condition or disease Intervention/treatment
Vitamin D Deficiency Other: In vivo immunity model

Detailed Description:
Vitamin D is mainly obtained from the sun and follows a seasonal pattern, with Vitamin D levels peaking in summer and reaching a trough during winter. Vitamin D deficiency is associated with impaired immunity. However, knowledge of Vitamin D deficiency with in vivo immunity is limited. This observational study aims to investigate the relationship between Vitamin D status and the in vivo immunity.

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Study Type : Observational
Actual Enrollment : 264 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Vitamin D Status and in Vivo Immune Function
Study Start Date : April 2014
Actual Primary Completion Date : December 2015
Actual Study Completion Date : December 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Vitamin D

Group/Cohort Intervention/treatment
Army recruits
Army recruits at the start of basic training will complete an in vivo immunity model
Other: In vivo immunity model
A measure of in vivo immune function.




Primary Outcome Measures :
  1. Vitamin D measured by liquid chromatography tandem mass spectroscopy [ Time Frame: Up to 20 months ]
    Circulating 25-hydroxy-vitamin D


Secondary Outcome Measures :
  1. Immune function measured by analytic biochemistry assay [ Time Frame: Up to 20 months ]
    In vivo immune measure


Biospecimen Retention:   Samples Without DNA
Blood serum collected at Week 1 (start of training) and Week 13 (end of training).


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Young adults who are starting basic training in the army.
Criteria

Inclusion Criteria:

  • Passed medical assessment by medical doctor
  • Passed audio test (this is part of medical assessment)
  • Met physical fitness requirements

Exclusion Criteria:

• Medically deferred by medical doctor


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02416895


Locations
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United Kingdom
Infantry Training Centre
Catterick, North Yorkshire, United Kingdom, DL9 3PS
Sponsors and Collaborators
Bangor University
University of East Anglia
Investigators
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Principal Investigator: Julie Greeves, PhD HQ Army Research and Training Division
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Bangor University
ClinicalTrials.gov Identifier: NCT02416895    
Other Study ID Numbers: 165/Gen/10
First Posted: April 15, 2015    Key Record Dates
Last Update Posted: April 5, 2017
Last Verified: March 2017
Additional relevant MeSH terms:
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Vitamin D Deficiency
Avitaminosis
Deficiency Diseases
Malnutrition
Nutrition Disorders