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Prevalence and Predictors of Depression in COPD

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02415140
Recruitment Status : Completed
First Posted : April 14, 2015
Last Update Posted : April 14, 2015
Information provided by (Responsible Party):
Tse Hoi Nam, Kwong Wah Hospital

Brief Summary:

Depression adversely affects quality of life in COPD patients, associated with higher rate of exacerbations, admissions and mortality. However, local prevalence rate of depression in geriatric COPD patients remains unknown.

Though BODE index is superior to FEV1 in prediction of depression in COPD, it is unclear which domain of BODE correlates best with depression. Furthermore, with multiple confounding factors, it's ambiguous that whether frequent exacerbation is an 'independent' predictor for depression among COPD patients.

The objective of this study is i.) to study the local prevalence rate of depression in geriatric COPD patients, ii.) to identify risk factors for depression especially looking at the any independent relationship between frequent exacerbations, various domains of BODE index and depression.

Condition or disease Intervention/treatment
Depression COPD Other: Rate of depression

Detailed Description:
This study is a multi-centers, cross-sectional study, conducted in Kwong Wah Hospital and Wong Tai Sin Hospital, Hong Kong SAR. Age and comorbidity-matched COPD and control subjects were recruited from clinics. Depressive symptoms were measured by a validated Chinese version of Geriatric Depression Scale short form (GDS - 15 items) with 2 cut-off points. A score of 8 or above was considered significant depressive symptoms while the cut off score of 5 or above was for patients with mild depressive symptoms. Prevalence rates of depressive symptoms were measured in both COPD and control groups. Predictors for depression (GDS = or> 8) were determined using univariate and multivariate analysis.

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Study Type : Observational
Actual Enrollment : 161 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Prevalence and Independent Predictors of Depression in COPD
Study Start Date : October 2013
Actual Primary Completion Date : February 2015

Resource links provided by the National Library of Medicine

Group/Cohort Intervention/treatment
Spirometry confirmed COPD patients
Other: Rate of depression
normal geriatric patients without lung disease
Other: Rate of depression

Primary Outcome Measures :
  1. Prevalence of depression (Prevalence rate) [ Time Frame: 1 year ]

Information from the National Library of Medicine

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Ages Eligible for Study:   60 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
COPD patients with spirometry confirmed airflow limitation

Inclusion Criteria:

  • aged 60 or above,
  • with stable COPD suggested clinically and
  • post-bronchodilator spirometry FEV1/FVC ratio <0.7.

Exclusion Criteria:

  • Patients were excluded if they had co-existing pulmonary diseases like active pulmonary tuberculosis, interstitial lung diseases etc;
  • if they were too demented or physically incapacitated to participate e.g wheelchair-bound for bedbound.

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Responsible Party: Tse Hoi Nam, Associate Consultant, Kwong Wah Hospital Identifier: NCT02415140     History of Changes
Other Study ID Numbers: KW/EX-13-142 (70-02)
First Posted: April 14, 2015    Key Record Dates
Last Update Posted: April 14, 2015
Last Verified: April 2015

Additional relevant MeSH terms:
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Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders