Effect of an Alpha-linolenic Acid-rich Supplement on Ketogenesis and Plasma Fatty Acids
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|ClinicalTrials.gov Identifier: NCT02410161|
Recruitment Status : Completed
First Posted : April 7, 2015
Results First Posted : February 18, 2019
Last Update Posted : February 18, 2019
Background: As the main alternative fuel to glucose for the brain, increased plasma ketones could potentially help compensate for brain glucose hypometabolism occurring during aging. The precursor long-chain n-3 polyunsaturated fatty acid (PUFA), α-linolenic acid (ALA), is normally mostly β-oxidized and so could potentially be used to stimulate ketogenesis in humans.
Objective: To compare the impact of an ALA-rich supplement on the ketogenic response in young and older healthy adults.
Design: Ten young and ten older adults will consume a flaxseed oil supplement providing 2 g/d of ALA for 4 weeks. Plasma ketones, free fatty acids, triglycerides, glucose and insulin will be measured over 6 h during two metabolic study days, one before and one at the end of the supplementation.
Hypothesis: ALA-rich supplement for 4 weeks will increase ketone production in both groups.
|Condition or disease||Intervention/treatment||Phase|
|Healthy||Dietary Supplement: alpha-linolenic acid-rich supplement||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Single Group Assignment|
|Intervention Model Description:||Dietary Supplement: alpha-linolenic acid-rich supplement|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Effect of an Alpha-linolenic Acid-rich Supplement on Ketogenesis and Plasma n-3 Polyunsaturated Fatty Acids in Young Compared to Older Adults|
|Study Start Date :||July 2013|
|Actual Primary Completion Date :||May 2014|
|Actual Study Completion Date :||May 2014|
Experimental: 4 week ALA treatment
Participants will receive the alpha-linolenic acid-rich supplement (1000mg 4 times par day) for 4 weeks
Dietary Supplement: alpha-linolenic acid-rich supplement
each participant consumed one 1000 mg capsule of flaxseed oil four times per day for 4 weeks, providing a total of 2 g/d of ALA. The capsules used were a commercially available flaxseed oil supplement containing ALA at 56% of total fatty acids (Jamieson, Toronto, ON, Canada). The other main fatty acids present in flaxseed oil include linoleic acid (18%), oleic acid (16%), palmitic and stearic acid (10% combined).
- Ketone Production [ Time Frame: After 4 weeks ]Total Ketone (acetoacetate + beta-hydroxybutyrate) concentration in plasma in average during the metabolic study day, measured hourly between 1 and 6h after breakfast
- Plasma Glucose [ Time Frame: After 4 weeks ]Glucose measured in plasma in average during the metabolic study day, measure hourly between 0 and 6 h after breakfast
- Plasma Triglycerides [ Time Frame: After 4 weeks ]Triglycerides measured in plasma in average during the metabolic study day, measured hourly between 1 to 6h after breakfast
- Plasma Free Fatty Acids [ Time Frame: 4 weeks ]Free fatty acids measured in plasma in average during the metabolic study day, measured hourly between 1 to 6h after breakfast
- Insulin Concentration in Plasma [ Time Frame: after 4 weeks ]Insulin measured in plasma in average during the metabolic study day, measured hourly between 0 ans 6 h after breakfast
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02410161
|Principal Investigator:||Stephen Cunnane, PhD||Université de Sherbrooke|