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An Open-Label, Phase 2a Study to Evaluate Safety and Efficacy of GR-MD-02 for Treatment of Psoriasis

This study is enrolling participants by invitation only.
Sponsor:
ClinicalTrials.gov Identifier:
NCT02407041
First Posted: April 2, 2015
Last Update Posted: August 1, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Galectin Therapeutics Inc.
  Purpose
Study GT-030 is a phase 2a, single-center, open-label study of subjects with moderate to severe plaque psoriasis

Condition Intervention Phase
Psoriasis Drug: GR-MD-02 Phase 2

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Single-Center, Open-Label Phase 2a Clinical Trial to Evaluate the Safety and Efficacy of GR-MD-02 for the Treatment of Patients With Moderate to Severe Plaque Psoriasis

Resource links provided by NLM:


Further study details as provided by Galectin Therapeutics Inc.:

Primary Outcome Measures:
  • The primary endpoint will be PASI-75, or a 75% improvement from baseline (day 1, prior to first infusion) in PASI score as assessed at the 30 day follow up visit. [ Time Frame: 12 weeks ]

Secondary Outcome Measures:
  • PASI-50 and PASI-100 scores, or a 50% and 100% improvement from baseline following the first 12 weeks of therapy with GR-MD-02 [ Time Frame: 12 weeks ]
  • PASI-50, PASI-75, and PASI-100 score improvement from baseline in patients following an additional 12 weeks of therapy (total 24 weeks) with GR-MD-02 [ Time Frame: 24 weeks ]
  • Durability of response (change in response) over a one year six-month period from the end of therapy [ Time Frame: 18 months ]
  • Any change in disease status of patients who also have psoriatic arthritis [ Time Frame: 24 weeks ]
  • Incidence of adverse events and vital sign and laboratory abnormalities [ Time Frame: 24 weeks ]

Estimated Enrollment: 10
Study Start Date: September 2015
Estimated Study Completion Date: March 2018
Estimated Primary Completion Date: March 2018 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: GR-MD-02
active arm
Drug: GR-MD-02
IV infusion
Other Name: galactoarabino-rhamnogalacturonate

Detailed Description:

The overall objective is to establish the safety and efficacy of GR-MD-02 in patients with moderate to severe plaque psoriasis.

Primary objective:

The objective is to evaluate the number of patients with moderate to severe plaque psoriasis who have 75% improvement in Psoriasis Activity Severity Index (PASI-75) following 12 weeks of therapy with GR-MD-02

Secondary objectives:

  • To determine the PASI-50 and PASI-100 scores in patients with moderate to severe plaque psoriasis following the first 12 weeks of therapy with GR-MD-02
  • To determine the PASI-50, PASI-75, and PASI-100 scores in patients with moderate to severe plaque psoriasis following an additional 12 weeks of therapy (total 24 weeks) with GR-MD-02
  • To determine the durability of response to therapy in responders over a one year period following the end of therapy
  • To determine whether there is any change in disease status of patients who also have psoriatic arthritis
  • To determine the incidence of adverse events and vital sign and laboratory abnormalities during study treatment
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Each subject must meet all of the following criteria to be enrolled in this study:

  1. Is capable of understanding the written informed consent, provides signed and witnessed written informed consent, and agrees to comply with protocol requirements.
  2. Is between the ages of 18 and 75 years.
  3. Has biopsy proven psoriasis and active moderate to severe plaque psoriasis with a PASI of ≥ 12 and at least 10% of involved body surface area.
  4. The patient is not pregnant and must have a negative pregnancy test prior to start of the study. Post-menopausal women must have been amenorrheic for at least 12 months to be considered of non-child-bearing potential.
  5. Sexually active men or women of childbearing potential must agree to use effective means of contraception throughout their participation in this study and for 90 days after discontinuation of study medication.
  6. Lactating females must agree to discontinue nursing before the start of study treatment and refrain from nursing until 90 days after discontinuation of study medication.
  7. Male subjects must refrain from sperm donation throughout the study period and for a period of 90 days following the last dose of study drug.

Exclusion Criteria:

Subjects meeting any of the following criteria will be excluded from the study:

  1. Any medical illness that is not stable on therapy
  2. Use of any biologic medication for psoriasis within 6 months
  3. Use of or non-biological systemic therapy to include: methotrexate, oral retinoids, phototherapy/PUVA, cyclosporine, or any other cytotoxic or immunosuppressive medication within 4 weeks of start of study
  4. Topical treatment that is likely to impact signs and symptoms of psoriasis, in the opinion of the Principal Investigator, within 2 weeks of the start of the study
  5. Prior exposure to GR-MD-02
  6. Known positivity for Human Immunodeficiency Virus (HIV) infection
  7. Any patient who had major surgery within 8 weeks of Day 1, significant traumatic injury, or anticipation of need for major surgical procedure during the study.
  8. Has a history of alcohol/drug abuse.
  9. Any patient who has clinically significant and uncontrolled cardiovascular disease (e.g., uncontrolled hypertension, myocardial infarction, unstable angina), New York Heart Association (NYHA) Grade II or greater congestive heart failure, serious cardiac arrhythmia requiring medication, or Grade II or greater peripheral vascular disease within 12 months prior to Day 1.
  10. Any patient with concurrent infection including diagnoses of fever of unknown origin (FUO) (subjects must be afebrile at the start of therapy).
  11. History of malignant disease with a recurrence of that disease within 5 years of follow-up except for those that have been curatively treated including basal or squamous cell carcinoma of the skin and in situ carcinoma of the cervix
  12. Participation in an investigational new drug (IND) trial in the 30 days before randomization.
  13. Clinically significant medical or psychiatric condition considered a high risk for participation in an investigational study.
  14. Has donated or lost a significant volume (>450 mL) of blood or plasma within 30 days of the study.
  15. Failure to give informed consent
  16. Subjects with known allergies to the study drug or any of its excipients.
  17. Is an employee or family member of the investigator or study site personnel.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02407041


Locations
United States, Texas
Brooke Army Medical Ctr.
San Antonio, Texas, United States, 78234
Sponsors and Collaborators
Galectin Therapeutics Inc.
  More Information

Responsible Party: Galectin Therapeutics Inc.
ClinicalTrials.gov Identifier: NCT02407041     History of Changes
Other Study ID Numbers: GT-030
First Submitted: March 30, 2015
First Posted: April 2, 2015
Last Update Posted: August 1, 2017
Last Verified: July 2017

Additional relevant MeSH terms:
Psoriasis
Skin Diseases, Papulosquamous
Skin Diseases