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A Study to Determine the Efficacy of Topically Applied MTC896 Gel in Subjects With Acne Vulgaris

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ClinicalTrials.gov Identifier: NCT02395549
Recruitment Status : Unknown
Verified June 2016 by Mimetica Pty Limited.
Recruitment status was:  Active, not recruiting
First Posted : March 23, 2015
Last Update Posted : June 16, 2016
Sponsor:
Information provided by (Responsible Party):
Mimetica Pty Limited

Brief Summary:
This study is designed to investigate the efficacy, safety and tolerability of MTC896 Gel in subjects with acne. In this study, MTC896 Gel will be applied at 3 concentrations, twice daily (bid) for 12 weeks and compared against a vehicle control.

Condition or disease Intervention/treatment Phase
Acne Vulgaris Drug: 0.375% (w/w) MTC896 Gel Drug: 0.75% (w/w) MTC896 Gel Drug: 1.5% (w/w) MTC896 Gel Drug: Vehicle Control Gel Phase 2

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 364 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Study Start Date : April 2015
Actual Primary Completion Date : June 2016
Estimated Study Completion Date : August 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Acne

Arm Intervention/treatment
Experimental: 0.375% (w/w) MTC896 Gel
0.375% (w/w) MTC896 Gel will be applied bid to the whole face for 12 weeks.
Drug: 0.375% (w/w) MTC896 Gel
0.375% (w/w) MTC896 Gel

Experimental: 0.75% (w/w) MTC896 Gel
0.75% (w/w) MTC896 Gel will be applied bid to the whole face for 12 weeks.
Drug: 0.75% (w/w) MTC896 Gel
0.75% (w/w) MTC896 Gel

Experimental: 1.5% (w/w) MTC896 Gel
1.5% (w/w) MTC896 Gel will be applied bid to the whole face for 12 weeks.
Drug: 1.5% (w/w) MTC896 Gel
1.5% (w/w) MTC896 Gel

Placebo Comparator: Vehicle Control Gel
Vehicle Control Gel will be applied bid to the whole face for 12 weeks.
Drug: Vehicle Control Gel



Primary Outcome Measures :
  1. Absolute change from baseline in inflammatory lesion counts [ Time Frame: Week 12 ]
  2. Absolute change from baseline in noninflammatory lesion counts [ Time Frame: Week 12 ]
  3. Proportion of subjects with Investigator‟s Global Assessment (IGA) success [ Time Frame: Week 12 ]
    i.e., who achieved a minimum 2-grade improvement from baseline


Secondary Outcome Measures :
  1. Percent change from baseline in inflammatory lesion counts [ Time Frame: Weeks 4, 8 and 12 ]
  2. Percent change from baseline in noninflammatory lesion counts [ Time Frame: Weeks 4, 8 and 12 ]
  3. Percent change from baseline in total lesion counts [ Time Frame: Weeks 4, 8 and 12 ]
  4. Absolute change from baseline in inflammatory lesion counts [ Time Frame: Weeks 4 and 8 ]
  5. Absolute change from baseline in noninflammatory lesion counts [ Time Frame: Weeks 4 and 8 ]
  6. Absolute change from baseline in total lesion counts [ Time Frame: Weeks 4, 8 and 12 ]
  7. Proportion of subjects with IGA success [ Time Frame: Weeks 4 and 8 ]
    i.e. who achieved a minimum 2-grade improvement from baseline

  8. Time to IGA success [ Time Frame: Week 12 ]
  9. Proportion of subjects who achieved at least a 2 grade reduction and an IGA score of clear or almost clear [ Time Frame: Weeks 4, 8 and 12 ]
  10. Proportion of subjects who achieved a "Clear" or "Almost Clear" IGA score [ Time Frame: Weeks 4, 8 and 12 ]


Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years to 65 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Is a male or nonpregnant, non-lactating, non-breastfeeding female, 16 to 65 years of age, inclusive, at the time of screening;
  2. Has provided written informed consent/assent (which includes consent for photographs, if applicable, to be taken at Baseline and end-of-treatment/end-of-study [EOT/EOS] visits);
  3. Has been diagnosed with mild-to-severe acne vulgaris defined as:

    • At least 20 inflammatory lesions,
    • At least 20 noninflammatory lesions,
    • ≤ 2 nodular lesions, and
    • Investigator Global Assessment of 2 or greater;
  4. Is willing to comply with the requirements of the protocol;
  5. If female and of child-bearing potential or premenarcheal, has a negative urine pregnancy test at Screening and Baseline / Day 1 and is willing to use effective contraception during the study and for 30 days after the last study medication application. Females are considered to be of childbearing potential unless surgically sterilized (hysterectomy, bilateral oophorectomy, tubal ligation), diagnosed as infertile, or are postmenopausal for at least 1 year; (Acceptable methods of birth control are defined as: abstinence, oral contraceptives, contraceptive patches/implants, Depo-Provera®, double barrier methods (e.g. condom and spermicide) or an intrauterine device (IUD). Birth control method must have been stable/unchanged for 12 weeks prior to Baseline and must remain unchanged during study participation);
  6. If male, has been vasectomized or agrees to use an accepted method of birth control with female partner during study participation and for 30 days after the last study medication application;
  7. Is in good health and free from any disease which, in the opinion of the Investigator, would put the subject at risk if participating in the study;
  8. Is free of any systemic or dermatologic disorder, which, in the opinion of the Investigator, will interfere with the study results or increase the risk of adverse events;
  9. Is willing to abstain from using any facial treatment products on the face during the study (continued use of make-up is permitted but may not be changed within 2 weeks prior to the study period or during the entire study period);
  10. Is willing to avoid sun exposure and to protect the face with a hat/visor; sunscreen use is recommended/allowed when sun exposure cannot be avoided;
  11. If male, must agree to shave the treatment area and must agree not to alter his routine shaving regimen for the duration of the study;
  12. Is willing to refrain from using any treatments, other than the study medication, including antibiotics, for acne present on the face. Topical acne treatments that do not have significant or measurable systemic absorption (e.g. benzoyl peroxide, salicylic acid) are allowed for treatment of acne of the back, shoulders, and chest only.

Exclusion Criteria:

  1. People who would otherwise qualify for the study, but are living in the same household as a study subject, are not allowed to participate in the study;
  2. Pregnant or lactating or plan to become pregnant within 1 month (30 days) of study completion;
  3. Known allergy/sensitivity to any of the study medication components;
  4. Any skin condition which may interfere with the evaluation of safety or of acne vulgaris (e.g. rosacea, seborrheic dermatitis, perioral dermatitis, corticosteroid-induced acne or folliculitis);
  5. Excessive facial hair that would interfere with diagnosis or assessment of acne vulgaris;
  6. Excessive sun exposure, in the opinion of the Investigator, or use of tanning booths;
  7. Active cystic acne or acne conglobata, acne fulminans, and secondary acne;
  8. Screening clinical chemistry or hematology laboratory value that is considered clinically significant, in the opinion of the Investigator;
  9. Participation in an investigational drug study within 30 days prior to Screening;
  10. Is a poor medical risk because of other systemic diseases or active uncontrolled infections, in the opinion of the Investigator;
  11. Any other condition which, in the judgment of the Investigator, would put the subject at unacceptable risk for participation in the study;
  12. Within 9 months (270 days) prior to Baseline and throughout the study:

    - Oral retinoid use (e.g. isotretinoin);

  13. Within 6 months (180 days) prior to Baseline and throughout the study:

    - Treatment with Vitamin A supplements greater than 10,000 units/day;

  14. Within 3 months (90 days) prior to Baseline and throughout the study:

    • Use of androgen receptor blockers (such as spironolactone or flutamide);
    • Initiation of treatment with hormonal therapy or dose change to hormonal therapy;
    • Dose and frequency of use of any hormonal therapy started more than 3 months (90 days) prior to Baseline must remain unchanged throughout the study;
    • Hormonal therapies include, but are not limited to, testosterone, anabolic steroids, birth control pills;
  15. Within 8 weeks (56 days) prior to Baseline and throughout the study:

    - Facial procedures (chemical or laser peel, microdermabrasion, etc.);

  16. Within 4 weeks (28 days) prior to Baseline and throughout the study:

    • Treatment with systemic corticosteroids (including intranasal and inhaled corticosteroids);
    • Treatment with systemic antibiotics or systemic anti-acne drugs or systemic anti-inflammatory drugs; Note: Non-steroidal anti-inflammatory drugs (NSAIDs) and aspirin use on an as-needed basis and if not used consecutively for >14 days prior to Baseline is acceptable and does not require washout. Low dose (81 mg) aspirin taken daily is acceptable.
    • Prescription topical retinoid use on the face (e.g. tretinoin, tazarotene, adapalene);
    • Antifungals, antiretrovirals and antibiotics included in the CYP 3A4 and CYP 3A5;
  17. Within 2 weeks (14 days) prior to Baseline and throughout the study:

    • Treatment with topical prescription antibiotics (e.g. dapsone, clindamycin, erythromycin, or sulfacetamide);
    • Treatment with over-the-counter (OTC) topical medications for the treatment of acne vulgaris including benzoyl peroxide, topical anti-inflammatory medications, corticosteroids, α-hydroxy/glycolic acid on the face;
  18. Within 1 day prior to Baseline and throughout the study:

    • Grapefruit juice which is included in the CYP 3A4 and CYP 3A5.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02395549


Locations
United States, California
Sacramento, California, United States
San Diego, California, United States, 92108
San Diego, California, United States, 92123
United States, Colorado
Denver, Colorado, United States
United States, Florida
Sanford, Florida, United States
West Palm Beach, Florida, United States
United States, Kentucky
Louisville, Kentucky, United States
United States, Michigan
Warren, Michigan, United States
United States, Minnesota
Minneapolis, Minnesota, United States
United States, New Mexico
Albuquerque, New Mexico, United States
United States, North Carolina
High Point, North Carolina, United States
United States, Pennsylvania
Hershey, Pennsylvania, United States
United States, Rhode Island
Johnston, Rhode Island, United States
Warwick, Rhode Island, United States
United States, Tennessee
Nashville, Tennessee, United States
United States, Texas
Austin, Texas, United States
College Station, Texas, United States
Plano, Texas, United States
United States, Utah
Salt Lake City, Utah, United States
United States, Washington
Spokane, Washington, United States
Sponsors and Collaborators
Mimetica Pty Limited
Investigators
Study Director: Debra Dow Symbio, LLC

Responsible Party: Mimetica Pty Limited
ClinicalTrials.gov Identifier: NCT02395549     History of Changes
Other Study ID Numbers: MCL15001
First Posted: March 23, 2015    Key Record Dates
Last Update Posted: June 16, 2016
Last Verified: June 2016

Additional relevant MeSH terms:
Acne Vulgaris
Acneiform Eruptions
Skin Diseases
Sebaceous Gland Diseases