Long-term Outcome Related Prognostic Factor and Biomarkers of Major Trauma Database Analysis
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|ClinicalTrials.gov Identifier: NCT02367768|
Recruitment Status : Recruiting
First Posted : February 20, 2015
Last Update Posted : March 17, 2015
|Condition or disease|
|Wounds and Injuries|
Severe traumatic injury occupied the sixth leading cause of death in Taiwan, especially in young adults. In 2013, there were accidental deaths in every 76 minutes. Not compared with the malignancy, heart disease, cerebrovascular disease, diabetes mellitus, or pneumonia Since 1995, Taiwan replaced a previous patchwork of separate social health insurance funds with one single-payer, National Health Insurance (NHI) scheme that is administered by an agency of the central government's Department of Health. NHI supported the cost of Critical Illness and Injury that numerous patients with major trauma were eligible for preference. However, the national medical cost of trauma care, especially in poly-trauma or major trauma were impressive: the adjusted national inpatient trauma yearly costs were estimated at $37,511,328,659 US dollars; the national insurance cost provided by Bureau of National Health Insurance, Department of Health for trauma was over $20,000,000,000 new Taiwan dollars till 1999 with increasing yearly.
Recently it flashed bulletins nationwide and overseas for catastrophes, such as aircraft accident, wrecks, or underground gas explosions. There was a stirring of interest in life support system for major trauma related rescue from dying. Death to trauma is caused by costly damages on scene, hemorrhage shock or trauma and massive transfusion related acute respiratory distress syndrome (ARDS). Extra-Corporeal Membrane Oxygenation (ECMO) can rescue life from severe cardiopulmonary failure, but coexisting complication as bleeding and coagulopathy restricting the utilization the use in trauma patients. Besides, there were more portable ECMO sets making a debut, especially for air transportation. It act now the medical transferral for trauma patients under ECMO support. The portable ECMO sets launched with possibility, accessibility, and convenience. The issue of life support system utilization, long-term outcome, and medical cost-effectiveness for major trauma patients was worth discussing no matter in National Taiwan University Hospital (NTUH) trauma database or National Health Insurance Research Database (NHIRD).
Immune system alteration was previously considered the mechanism of post-traumatic stress disorder (PTSD). Moreover, an externally experienced traumatic event induces downstream alterations in immune function by reducing methylation.
|Study Type :||Observational|
|Estimated Enrollment :||500 participants|
|Official Title:||Long-term Outcome Related Prognostic Factor and Biomarkers of Major Trauma Database Analysis|
|Study Start Date :||February 2015|
|Estimated Primary Completion Date :||January 2020|
|Estimated Study Completion Date :||January 2020|
- Event related survival [ Time Frame: 30 days ]since major trauma event till trauma related death
- Functional status [ Time Frame: 12 months ]Besides Rehabilitation Complexity Scale (RCS) and Functional Independence Measure (FIM) for traumatic brain injury patients, Glasgow Outcome Scale - Extended (GOS-E) and European Quality of Life Five Dimensions Questionnaire (EQ-5D) are used in concerning longer-term outcome indicators. There are currently no robust measures of patient experience for use in major trauma. Functional status after the major trauma event could be measured using non-clinical outcomes such as return to work, maintenance of education and societal dependency at post injury 3, 6, and 12 months.
- over all survival [ Time Frame: 2 years ]since major trauma event till death
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02367768
|Contact: Ying-Ru Chen, Masterfirstname.lastname@example.org|
|Contact: Ying-Ru Chen, Master||886972651471|
|National Taiwan University Hospital||Recruiting|
|Taipei City, Taiwan, 100|
|Contact: Ting-Chun Kuo 886-97265-3245 email@example.com|
|Principal Investigator:||Ting-Chun Kuo, M.D.||No.7, Chung San South Road, Taipei City 100, Taiwan (R.O.C.)|