Analysis of CA-MRSA Transmission: An ED Population Sampling Strategy
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|ClinicalTrials.gov Identifier: NCT02363166|
Recruitment Status : Recruiting
First Posted : February 13, 2015
Last Update Posted : June 7, 2021
|Condition or disease||Intervention/treatment|
|Methicillin-Resistant Staphylococcus Aureus||Other: Acute Abscess Group|
Prospective cross-sectional study involving 500 patients enrolled over a one year period at the UFHealth Shands Hospital's Adult and Pediatric Emergency Department. The collected information will serve as pilot data for a future large comprehensive multi-site study.
Patients will have a wound culture and a nasal swab obtained as part of the study, which will be assessed for MRSA isolates using next-generation whole genome sequencing. The principal investigator or PI designee will also survey participants and review hospital records.
|Study Type :||Observational|
|Estimated Enrollment :||575 participants|
|Official Title:||Molecular Epidemiology and Phylodynamic and Phylogeographic Analysis of Community-associated Methicillin-resistant Staphylococcus Aureus (CA-MRSA) Transmission: An Emergency Department Population Sampling Strategy|
|Actual Study Start Date :||August 2015|
|Estimated Primary Completion Date :||February 2022|
|Estimated Study Completion Date :||February 2022|
Acute Abscess Group
Adults and pediatric patients presenting to the UFHealth Shands Emergency Department with evidence of an acute abscess, or skin/soft tissue infection, which can be sampled for culture and sensitivity testing will be recruited.
Other: Acute Abscess Group
Samples collected for culture and sensitivity testing depending on acute abscess, or skin/soft tissue infection.
- Strain Relatedness Identification Through Phylogenetic Analysis [ Time Frame: 1 Hour ]Molecular (spa-typing) and genomic (WGS) relatedness of MRSA strains in isolates in ED populations presenting with SSTIs.
- Strain Transmission Through Analysis of Genetic Clustering [ Time Frame: 1 year ]Phlyodynamic analysis of MRSA transmission course by strain
- Patient Level Characteristics of Skin and Soft Tissue Infection (SSTI) Presentation [ Time Frame: 6 Months ]To determine patient-level characteristics, including social and medical history, associated with a presentation related to SSTIs.
- Pediatric and Adult Population Presentation Characteristics in Skin and Soft Tissue Infection (SSTI) [ Time Frame: 6 Months ]Compare patient-level characteristics and phylogenetic clustering between pediatric and adult patients presenting with SSTIs.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02363166
|Contact: Joseph A Tyndall, MDfirstname.lastname@example.org|
|Contact: Scott Cohenemail@example.com|
|Principal Investigator:||Joseph A Tyndall, MD||University of Florida|