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Genetics of Uveitis

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ClinicalTrials.gov Identifier: NCT02357238
Recruitment Status : Recruiting
First Posted : February 6, 2015
Last Update Posted : July 23, 2019
Sponsor:
Information provided by (Responsible Party):
Sunil Srivastava, The Cleveland Clinic

Brief Summary:
In order to improve the investigators knowledge about uveitis and the underlying mechanism of disease, the investigators propose collecting blood from patients with uveitis, isolating DNA and sequencing the DNA to identify genetic mutations or associations in these patients.

Condition or disease
Uveitis Infectious Uveitis

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Study Type : Observational [Patient Registry]
Estimated Enrollment : 1500 participants
Observational Model: Case-Control
Time Perspective: Prospective
Target Follow-Up Duration: 10 Years
Official Title: Genetics of Uveitis
Study Start Date : January 2011
Estimated Primary Completion Date : January 2021
Estimated Study Completion Date : January 2021

Resource links provided by the National Library of Medicine


Group/Cohort
Uveitis
Uveitis or infectious uveitis patients



Primary Outcome Measures :
  1. Non infectious uveitis [ Time Frame: 5 years ]
    Distinct uveitis conditions will have a polymorphism association or specific mutation.


Secondary Outcome Measures :
  1. Infectious uveitis [ Time Frame: 5 years ]
    Infectious uveitis (such as herpes associated uveitis, toxoplasmosis retinochoroiditis) will have specific polymorphisms/mutations in innate immune system genes which predispose the patient to infectious uveitis.


Biospecimen Retention:   Samples With DNA
Whole blood serum will be collected


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Ages Eligible for Study:   6 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Any patient able to sign an informed consent or child of age 6 with parental /guardian consent with the diagnosis of uveitis or infectious uveitis.
Criteria

Inclusion Criteria:

  • Any patient above with the diagnosis of uveitis.
  • Any patient with a diagnosis of infectious uveitis such as toxoplasmosis retinochoroiditis, herpes associated retinitis.

Exclusion Criteria:

  • Patients who are unable to give consent
  • Patients in whom an adequated blood sample can not be obtained.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02357238


Contacts
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Contact: Kimberly M Baynes, BSN, RN, COA 216-444-2566 baynesk@ccf.org

Locations
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United States, Ohio
Cleveland Clinic Foundation Recruiting
Cleveland, Ohio, United States, 44195
Contact: Kimberly M Baynes, COA    216-444-2566    baynesk@ccf.org   
Principal Investigator: Sunil K. Srivastava, M.D.         
Sponsors and Collaborators
The Cleveland Clinic
Investigators
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Principal Investigator: Sunil K. Srivastava, M.D. The Cleveland Clinic

Additional Information:

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Responsible Party: Sunil Srivastava, Staff physician, The Cleveland Clinic
ClinicalTrials.gov Identifier: NCT02357238     History of Changes
Other Study ID Numbers: 11-087
First Posted: February 6, 2015    Key Record Dates
Last Update Posted: July 23, 2019
Last Verified: July 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Keywords provided by Sunil Srivastava, The Cleveland Clinic:
Uveitis
Infectious
Additional relevant MeSH terms:
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Communicable Diseases
Infection
Uveitis
Uveal Diseases
Eye Diseases