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Brain, Brainstem, and Spinal Cord fMRI

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ClinicalTrials.gov Identifier: NCT02356315
Recruitment Status : Completed
First Posted : February 5, 2015
Last Update Posted : December 21, 2015
Sponsor:
Collaborator:
National Center for Complementary and Integrative Health (NCCIH)
Information provided by (Responsible Party):
Todd Parrish, Northwestern University

Brief Summary:
New advances in medical imaging have allowed for the measurement of brain activity related to chronic pain. In addition to the brain, the investigators aim to use functional magnetic resonance imaging to investigate pain processing in the brainstem and spinal cord in healthy subjects and chronic neck pain patients. The information gained from this study will increase the investigators understanding of how chronic pain is encoded in the nervous system and assist in developing more effective treatment strategies.

Condition or disease Intervention/treatment
Neck Pain Chronic Pain Other: Functional Magnetic Resonance Imaging

Detailed Description:
The experimental design is an observational (non-interventional) cross-sectional clinical study. The principal goal of the proposed research is to utilize functional magnetic resonance imaging to further investigate and characterize pain-related neural activity at the level of the brain, brainstem, and spinal cord in healthy subjects and chronic neck pain patients. Healthy subjects and chronic neck pain patients will be recruited and participate in a single session of data collection. For both the healthy and chronic neck pain groups, painful thermal stimuli will be applied over the skin of the upper extremity while whole brain, brainstem, and cervical spinal cord functional images are acquired (on separate scans). For the chronic neck pain group, additional scans (brain, brainstem, and cervical spinal cord) will be acquired while the subjects rate their spontaneous chronic neck pain.

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Study Type : Observational
Actual Enrollment : 13 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Investigating Pain Processing in the Brain, Brainstem, and Spinal Cord With fMRI
Study Start Date : January 2015
Actual Primary Completion Date : December 2015
Actual Study Completion Date : December 2015

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
Healthy subjects
Functional magnetic resonance imaging of healthy subjects
Other: Functional Magnetic Resonance Imaging
Functional magnetic resonance imaging will be performed to measure brain, brainstem, and spinal cord activity.

Chronic neck pain patients
Functional magnetic resonance imaging of chronic neck pain patients
Other: Functional Magnetic Resonance Imaging
Functional magnetic resonance imaging will be performed to measure brain, brainstem, and spinal cord activity.




Primary Outcome Measures :
  1. Functional magnetic resonance imaging [ Time Frame: 1.5-2.25 hours ]
    Use functional magnetic resonance imaging to characterize brain, brainstem, and spinal cord pain processing in healthy subjects (thermal pain) and chronic neck pain patients (thermal pain and spontaneous clinical pain).



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Ages Eligible for Study:   21 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy subjects and chronic neck pain patients recruited from the community
Criteria

Healthy subjects must meet all of the following inclusion criteria to participate in this study:

  1. Age between 21 and 60 years old
  2. Right-handed; not currently experiencing significant pain
  3. No history of a chronic pain syndrome such as fibromyalgia, complex regional pain syndrome, chronic low back pain, etc.

Chronic neck pain patients must meet all of the following inclusion criteria to participate in this study:

  1. Age between 21 and 60 years old
  2. Right handed; neck pain > 3 months duration; moderate neck pain score > 30 on VAS (0-100) 3) No history of a chronic pain syndrome (fibromyalgia, complex regional pain syndrome, chronic low back pain, etc.) other than chronic neck pain and its associated symptoms.

Participants meeting any of the following exclusion criteria at baseline will be excluded from study participation:

  1. Non-English speaking
  2. Signs of upper extremity sensation loss; history of significant cerebrovascular disease including (but not limited to) epilepsy, stroke, tumor, multiple sclerosis, meningitis
  3. History of major head trauma with sustained loss of consciousness; history of neurosurgery, ENT surgery, spine surgery, or cardiac surgery
  4. History of cardiac pacemaker or neurostimulator implantation
  5. History of significant medical illness including cardiovascular disease, uncontrolled diabetes, uncontrolled hypertension, cancer, chronic obstructive pulmonary disease, severe asthma requiring hospitalization for treatment, renal insufficiency requiring dialysis, etc.
  6. History of alcoholism or consistent drug use; current infection or fever; pregnancy (or possible pregnancy)
  7. History of metal working or injury with shrapnel or metal slivers
  8. Claustrophobia
  9. Piercings that are unable to be removed and tattoos older than 30 years

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02356315


Locations
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United States, Illinois
Center for Translational Imaging, Northwestern University
Chicago, Illinois, United States, 60611
Sponsors and Collaborators
Northwestern University
National Center for Complementary and Integrative Health (NCCIH)
Investigators
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Principal Investigator: Todd Parrish, PhD Northwestern University

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Responsible Party: Todd Parrish, Professor, Department of Radiology, Northwestern University
ClinicalTrials.gov Identifier: NCT02356315     History of Changes
Other Study ID Numbers: STU00067625
5F32AT007800-03 ( U.S. NIH Grant/Contract )
First Posted: February 5, 2015    Key Record Dates
Last Update Posted: December 21, 2015
Last Verified: December 2015

Keywords provided by Todd Parrish, Northwestern University:
Brain
Brain Stem
Spinal Cord
Neurophysiology
Magnetic Resonance Imaging

Additional relevant MeSH terms:
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Chronic Pain
Neck Pain
Pain
Neurologic Manifestations
Signs and Symptoms