Biomarkers in Acute Cardiac Care (BACC)
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|ClinicalTrials.gov Identifier: NCT02355457|
Recruitment Status : Recruiting
First Posted : February 4, 2015
Last Update Posted : May 3, 2018
|Condition or disease|
|Acute Coronary Syndrome Myocardial Infarction Chest Pain|
The primary aim of the study is to detect and evaluate new cardiac biomarkers, evaluate and improve acute coronary syndrome (ACS) risk scores, which takes into account clinical, gender specific, psycho-social and lifestyle-risk factors, protein patterns and genetic variability in addition to the classical risk factors with respect to the primary endpoint of acute myocardial infarction.
Secondary study aims are :
- To provide estimates for the incidence of ACS in patients presenting with recent onset chest pain;
- To provide accurate, quantifiable measures of precursors of ACS;
- DNA, RNA, cells, and serum/plasma for comprehensive genetic, gene expression and proteomic studies
- To explore the impact of ACS candidate genes on cardiovascular risk stratification by using genome-wide analyses and a biological systems approach;
- To explore proteins relevant for ACS;
- To allow the identification of new therapeutic targets;
- To evaluate the impact of socio-economic factors on ACS and CAD risk.
Patients will be followed up during the hospital stay. Afterwards a telephone follow-up will take place after 30 days, 6, 24 and 48 months.
|Study Type :||Observational [Patient Registry]|
|Estimated Enrollment :||3000 participants|
|Target Follow-Up Duration:||4 Years|
|Official Title:||Biomarkers in Acute Cardiac Care|
|Study Start Date :||July 2013|
|Estimated Primary Completion Date :||December 2019|
|Estimated Study Completion Date :||December 2021|
Suspected acute myocardial infarction
Patients with recent onset symptoms suggesting acute myocardial infarction
- Acute myocardial infarction as index event [ Time Frame: Months ]The primary endpoint of the study is acute myocardial infarction
- AMI, Mortality, heart failure and quality of life [ Time Frame: Years ]The secondary endpoint of the study is mortality, heart failure, quality of life.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02355457
|Contact: Johannes T Neumann, MD||0049407410 ext firstname.lastname@example.org|
|Contact: Dirk Westermann, MD||0049407410 ext email@example.com|
|Department of General and Interventional Cardiology, University Heart Center Hamburg||Recruiting|
|Hamburg, Germany, 20246|
|Contact: Mahir Karakas, MD 0049407410 ext 57975 firstname.lastname@example.org|
|Principal Investigator:||Dirk Westermann, MD||UHZ|
|Principal Investigator:||Stefan Blankenberg, MD||UHZ|