Neuronal and Behavioral Effects of Implicit Priming in Obese Individuals
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|ClinicalTrials.gov Identifier: NCT02347527|
Recruitment Status : Recruiting
First Posted : January 27, 2015
Last Update Posted : January 30, 2019
|Condition or disease||Intervention/treatment||Phase|
|Feeding Behavior Obesity Overweight||Behavioral: Active Implicit Priming Behavioral: Control Implicit Priming||Not Applicable|
One factor that may contribute to susceptibility to obesity is a high responsivity to high-calorie foods in terms of cognitive factors such as emotional associations, reward value or reinforcing properties of food. Many of these processes involve learned associations thought to develop via classical conditioning through repeated pairings with external stimuli, which can influence food preferences and intake. As such, improving our understanding of the neuronal mechanisms underlying these processes and attempting to modify them may be a useful strategy to promote weight loss and maintenance. Therefore, the proposed study aims to investigate the effects of altering food perception on neuronal responses and food intake behaviors by using implicit priming, in which positively or negatively valenced images are presented immediately prior to food images, but are not consciously perceived.
The project goals are to determine the impact of the implicit priming intervention on both brain responses to food cues and on food intake behaviors in overweight/obese individuals. Food image ratings and neuronal responses to visual food cues will be assessed before and after either (a) an active implicit priming intervention or (b) a control intervention. Following fMRI, food intake will be measured.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||100 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Neuronal and Behavioral Effects of Implicit Priming in Obese Individuals|
|Study Start Date :||May 2013|
|Estimated Primary Completion Date :||December 2019|
|Estimated Study Completion Date :||December 2019|
Experimental: Active Implicit Priming
Participants will complete active implicit priming, in which food images are implicitly primed (i.e., below conscious awareness) with images of positive or negative affect.
Behavioral: Active Implicit Priming
A 10-minute implicit priming intervention, associating food images with images of positive or negative valence.
Placebo Comparator: Control Implicit Priming
Participants will complete a control implicit priming intervention, which matches the active intervention, but with neutral stimuli as primes.
Behavioral: Control Implicit Priming
A 10-minute implicit priming intervention, associating food images with images of neutral valence.
- Change in Food Image Ratings [ Time Frame: Baseline to within 10 minutes post-intervention ]Food image ratings change from baseline, measured within 10 minutes post-intervention. Food images are rated on "desire to eat" by visual analogue scale (0-100).
- Neuronal Response to Food Cues [ Time Frame: Baseline to peak insula response (within 20 minutes post-intervention) ]Neuronal response while viewing visual food cues will be measured using functional magnetic resonance imaging (fMRI). Primary outcome is peak insula response change from baseline, as measured within 20 minutes after the intervention.
- Measure of Food Intake [ Time Frame: 1 hour post-intervention ]Ad libitum food intake measure
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02347527
|Contact: Jason R Tregellas, PhDfirstname.lastname@example.org|
|Contact: Kristina T Legget, PhDemail@example.com|
|United States, Colorado|
|University of Colorado Anschutz Medical Campus||Recruiting|
|Aurora, Colorado, United States, 80045|
|Contact: Kristina T Legget, PhD 303-724-5809 firstname.lastname@example.org|
|Contact: Jason R Tregellas, PhD 303-724-6232 email@example.com|
|Principal Investigator:||Jason R Tregellas, PhD||University of Colorado - Anschutz Medical Campus|
|Principal Investigator:||Kristina T Legget, PhD||University of Colorado - Anschutz Medical Campus|