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Over-night Effect of Dietary Fiber on Glucose Metabolism and Satiety

This study has been completed.
Information provided by (Responsible Party):
Jonna Sandberg, Lund University Identifier:
First received: January 15, 2015
Last updated: May 26, 2015
Last verified: May 2015
The experimental model is a semi-acute, over-night, study where the purpose is to evaluate food factors related to colonially derived regulation and satiety in healthy subjects.

Condition Intervention Phase
Metabolic Syndrome
Other: High levels of indigestible carbohydrates
Other: Low levels of indigestible carbohydrates
Early Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single Blind (Participant)
Primary Purpose: Prevention
Official Title: Indigestible Carbohydrates in an Over-night Design as Means to Modulate Colonic Events, With Specific Focus on Metabolism and Satiety

Resource links provided by NLM:

Further study details as provided by Lund University:

Primary Outcome Measures:
  • Blood Glucose, levels of glucose in blood [ Time Frame: Postprandial 0-180 min after breakfast ]
  • Insulin, levels of insulin in blood [ Time Frame: Postprandial 0-180 min after breakfast ]
  • Appetite hormones, levels of Peptide YY (PYY) in blood [ Time Frame: Postprandial 0-180 min after breakfast ]
  • Markers of colonic fermentation, levels of hydrogen in breath [ Time Frame: Postprandial 0-180 min after breakfast ]
  • Inflammation markers, levels of Interleukin-6 (IL-6) in blood [ Time Frame: Postprandial 0-180 min after breakfast ]

Secondary Outcome Measures:
  • Subjective satiety, as measured by VAS [ Time Frame: Postprandial 0-180 min after breakfast ]

Enrollment: 21
Study Start Date: October 2014
Study Completion Date: May 2015
Primary Completion Date: May 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: + ind. CHO
Test meals: intake of high levels of indigestible carbohydrates the evening prior to measurements of variables
Other: High levels of indigestible carbohydrates
Experimental: - ind. CHO
Reference meal: scarce intake of indigestible carbohydrates the evening prior to measurements of variables
Other: Low levels of indigestible carbohydrates


Ages Eligible for Study:   20 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Normal fasting blood glucose
  • BMI 19-25 kg/m2

Exclusion Criteria:

  • Gastrointestinal diseases
  • Food allergies e.g. lactose-, gluten intolerance
  • Metabolic disorder e.g. diabetes
  • Tobacco/snuff users
  • No antibiotic or probiotic intake 2 weeks prior and during study.
  • Vegetarians
  Contacts and Locations
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Please refer to this study by its identifier: NCT02347293

Medicon Village
Lund, Sweden
Sponsors and Collaborators
Lund University
Principal Investigator: Anne Nilsson, PhD Lund University
  More Information

Responsible Party: Jonna Sandberg, MSc, postgraduate student, Lund University Identifier: NCT02347293     History of Changes
Other Study ID Numbers: Dnr2013/241b
Study First Received: January 15, 2015
Last Updated: May 26, 2015

Additional relevant MeSH terms:
Metabolic Syndrome X
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases processed this record on May 23, 2017