Trial record 3 of 49 for:    "Dyslexia"

Maturation of Auditory Processing in Children With Dyslexia Compared to Average-reading Children (ASTRAUCOLE)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02345876
Recruitment Status : Active, not recruiting
First Posted : January 26, 2015
Last Update Posted : March 8, 2018
Information provided by (Responsible Party):
Hospices Civils de Lyon

Brief Summary:
The hypothesis of central auditory processing disorders has been advanced to explain the anomalies of the grapheme/phoneme combination in some dyslexia. These phonological disorders may be linked to abnormalities of the efferent (medial olivocochlear) system modulation and of cortical asymmetry. Indeed, the efferent system has an asymmetry in relation to handedness. Thus, in right-handed subject, it is predominant on the right side. In contrast, in the subject-handed dyslexic, the efferent system tends to be right-lateralized or non-lateralized. However, after an audio-visual training, normal lateralization can appear. This maturation of the efferent system lateralization during reading acquisition seems to have a particular profile in dyslexics with phonological disorder, especially if it is persistent. This finding allows to consider new prognostic evaluation and speech therapy rehabilitation in the dyslexic child.

Condition or disease Intervention/treatment
Dyslexia Other: no intervention

Study Type : Observational
Actual Enrollment : 161 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Asymmetry, Auditory Processing and Reading Skills in Phonological Dyslexic Children Compared to Average-reading Children
Actual Study Start Date : March 11, 2014
Estimated Primary Completion Date : June 7, 2019
Estimated Study Completion Date : June 7, 2019

Group/Cohort Intervention/treatment
Dyslexic children
Longitudinal follow-up without intervention
Other: no intervention
Normal reading children
Longitudinal follow-up without intervention
Other: no intervention

Primary Outcome Measures :
  1. Change of The Asymmetry Index of the efferent system at 2 years interval [ Time Frame: Day 1 and then at least 2 years (± 4 weeks) ]
    The change of the Asymmetry Index of the efferent system The Asymmetry Index is the difference between the equivalent attenuation measured on the right ear and the left ear. Evoked otoacoustic emissions were recorded monaurally at five stimulus intensities ranging from 57 to 69 dB SPL in 3 dB steps, in random presentation order, with and without contralateral acoustic stimulation consisting of 30 dBSPL continuous broadband noise (speech-like noise) produced by an audiometer

Secondary Outcome Measures :
  1. Change in the level of reading skill [ Time Frame: Day 1 and then at least 2 years (± 4 weeks) ]
    Behavioral measure

  2. Change in the percentage of correct answers obtained during a speech perception test in silence and noise. [ Time Frame: Day 1 and then at least 2 years (± 4 weeks) ]
    Oral repetition of VCV

  3. Change in percentage of correctly repeated stimuli which have been heard in both ears (binaural integration with divided attention) or in one indicated ear (binaural separation with selective attention) [ Time Frame: Day 1 and then at least 2 years (± 4 weeks) ]
    Presentation of different speech material to both ears simultaneously

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Ages Eligible for Study:   6 Years to 11 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
For the dyslexic children: primary care clinic and speech therapists For the normal reading children : elementary schools of Lyon and Clermond-Ferrand and their suburbs

Common inclusion criteria

  • Native French speaker and french education
  • No medical treatment for behavior or neurological disorders (as epilepsy)
  • Normal or corrected vision
  • Right-handed children (Edinburgh tets (Oldfield, 1971): >+50%)
  • Normal ORL examination
  • No hearing loss : hearing thresholds not above 15 dB between 250 and 4 000 Hz
  • Presence of Otoacoustic Emissions (Total amplitude < 5 dB or SNR > 3dB for at least 3 frequency bands between 1 and 4 kHz)
  • Normal level of intellectual development
  • Regular school attendance

For the normal reading children

  • Aged from 6 to less than 11
  • Normal reading level

For the dyslexic children

  • Aged from 8 to less than 11
  • Diagnostic of dyslexia made by a complet check-up during the 6 last months before the inclusion

Exclusion Criteria

  • Neurological or psychiatric disease incompatible with the testing procedure
  • Ear disease during more than 6 months
  • Normal reading children who have repeat a year
  • Previous speech therapy for normal reading children
  • Not corrected visual acuteness
  • Schooling in a foreign language
  • Foreign language spoken at home with both parents
  • Known hearing deficit
  • Invalid social security

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02345876

Centre Hospitzlier Le Vinatier
Bron, France, 69500
Service ORL CHU Montpied
Clermont-Ferrand, France, 63003
Service d'Audiologie et Explorations Orofaciales Centre de Référence des Troubles des Apprentissages
Lyon, France
Sponsors and Collaborators
Hospices Civils de Lyon

Responsible Party: Hospices Civils de Lyon Identifier: NCT02345876     History of Changes
Other Study ID Numbers: 2013-799
First Posted: January 26, 2015    Key Record Dates
Last Update Posted: March 8, 2018
Last Verified: March 2018

Keywords provided by Hospices Civils de Lyon:
Dyslexia, Medial olivocochlear system, Maturation, Auditory Processing

Additional relevant MeSH terms:
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Learning Disorders
Signs and Symptoms
Neurodevelopmental Disorders
Mental Disorders