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Cancer Development In Organ Transplant Recipients

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ClinicalTrials.gov Identifier: NCT02333279
Recruitment Status : Completed
First Posted : January 7, 2015
Last Update Posted : July 29, 2019
Sponsor:
Collaborators:
University Hospital, Basel, Switzerland
University Hospital Inselspital, Berne
Cantonal Hospital of St. Gallen
University Hospital, Geneva
University of Lausanne Hospitals
Information provided by (Responsible Party):
University of Zurich

Brief Summary:
The investigators will determine the cancer risk in organ transplant recipients compared to the general population with the help of statistical analysis. Secondly the investigators will try to characterize the different cancer types.

Condition or disease
Heart Cancer Kidney Cancer Lung Cancer Pancreas Cancer Liver Cancer

Detailed Description:
This cohort analyses will focus on incident and recurrent cases of development of non-skin cancer over time. We will consider time to first formation of non-skin solid cancer after solid organ transplantation as well as the cumulative number of non-skin solid cancer formation over time. Both aspects are equally important and will be reflected in the analytic methods of this study. Theses analyses will be restricted to the most prevalent transplantation types of heart, kidney, liver, and lung.

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Study Type : Observational [Patient Registry]
Actual Enrollment : 1800 participants
Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration: 5 Years
Official Title: Cancer Development In Organ Transplant Recipients
Actual Study Start Date : May 2008
Actual Primary Completion Date : May 2018
Actual Study Completion Date : July 2019

Resource links provided by the National Library of Medicine


Group/Cohort
Organ transplant recipients
Follow-ups in regular intervals following the organ transplant date.



Primary Outcome Measures :
  1. Number of solid cancers [ Time Frame: Ten Year followup ]
    Number of solid cancers



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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All solid organ transplant recipients in Switzerland since 2008 who have given their consent to be included in the study.
Criteria

Inclusion Criteria:

We will select all patients within the STCS based on the date of the first solid organ transplantation. Patients with multiple organ transplantations will be included as well. Patients contribute to the study observation time until death or end of follow-up due to other reasons.

Exclusion Criteria:

We will exclude patients with non-solid organ transplantation (e.g. hematopoietic stem cell transplantation), because the detailing of information in the STCS is insufficient to allow for detailed analysis of cancer development and control of relevant confounders. We will exclude


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02333279


Locations
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Switzerland
University Hospital Zurich, Division of Dermatology
Zurich, Switzerland, 8091
Sponsors and Collaborators
University of Zurich
University Hospital, Basel, Switzerland
University Hospital Inselspital, Berne
Cantonal Hospital of St. Gallen
University Hospital, Geneva
University of Lausanne Hospitals
Investigators
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Principal Investigator: Gunther FL Hofbauer, MD University Hospital, Zürich

Additional Information:

Publications of Results:
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Responsible Party: University of Zurich
ClinicalTrials.gov Identifier: NCT02333279     History of Changes
Other Study ID Numbers: FUP062
snctp000000587 ( Other Identifier: Swiss National Clinical Trials Portal )
First Posted: January 7, 2015    Key Record Dates
Last Update Posted: July 29, 2019
Last Verified: July 2019

Additional relevant MeSH terms:
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Liver Neoplasms
Kidney Neoplasms
Carcinoma, Renal Cell
Pancreatic Neoplasms
Heart Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Neoplasms
Digestive System Diseases
Liver Diseases
Urologic Neoplasms
Urogenital Neoplasms
Kidney Diseases
Urologic Diseases
Adenocarcinoma
Carcinoma
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Endocrine Gland Neoplasms
Pancreatic Diseases
Endocrine System Diseases
Thoracic Neoplasms
Heart Diseases
Cardiovascular Diseases