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Trial record 7 of 34 for:    "Osteoarthritis" | ( Map: Japan )

To Examine Whether or Not the Primary Causes of OA or RA Might be Bone Alterations

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ClinicalTrials.gov Identifier: NCT02327650
Recruitment Status : Recruiting
First Posted : December 30, 2014
Last Update Posted : November 22, 2018
Sponsor:
Information provided by (Responsible Party):
Yukio Nakamura, Shinshu University

Brief Summary:

Generally, osteoarthris (OA) is considered as primarily cartilage disease. However, as we and others have previously reported, a portion of OA might be caused primarily by bone alterations. In this study, we prospectively and retrospectively show that the bone altertations may affect OA primarily in all of the joints.

In addition, rheumatoid arthritis (RA) is a joint disease when immune system attacks synovium. Joint destruction occurrs continuously if suitable treatment is not performed. The etiology of RA is still largely unknown. As with OA, RA can be primarily damaged in bone, instead of cartilage. Here we prospectively and retrospectively show that the bone altertations may affect RA primarily in all of the joints.


Condition or disease Intervention/treatment
Progression of Rheumatoid Arthritis Osteoarthritis of Multiple Joints Procedure: The examinations for bones in joints of OA and RA patients

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Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: The Examinations Whether or Not the Primary Causes of Osteoarthritis or Rheumatoid Arthritis in Joints Might be Bone Alterations
Study Start Date : November 2015
Actual Primary Completion Date : April 2016
Estimated Study Completion Date : December 2019

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
RA and OA
Every 2 or 3 months, plain radiograph, blood and urinary tests, and MRI are performed in the painful joints of RA.
Procedure: The examinations for bones in joints of OA and RA patients



Primary Outcome Measures :
  1. The bone signal changes detected by MRI in OA and/or RA patients [ Time Frame: 1 year ]


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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
The patients who have OA with accompaying joint pain or the patients who have RA with accompaying joint pain
Criteria

Inclusion Criteria:

  • RA and/or OA

Exclusion Criteria:


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02327650


Locations
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Japan
Yukio Nakamura Recruiting
Matsumoto, Nagano, Japan, 3908621
Contact: Yukio Nakamura, MD, PhD    +81-263-37-2659    yxn14@aol.jp   
Principal Investigator: Yukio Nakamura, MD, PhD         
Yukio Nakamura Recruiting
Matsumoto, Japan
Contact: Yukio Nakamura       yxn14@aol.jp   
Sponsors and Collaborators
Shinshu University

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Responsible Party: Yukio Nakamura, Assistant Professor, Shinshu University
ClinicalTrials.gov Identifier: NCT02327650     History of Changes
Other Study ID Numbers: OA RA Bone Study
First Posted: December 30, 2014    Key Record Dates
Last Update Posted: November 22, 2018
Last Verified: November 2018

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
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Arthritis
Osteoarthritis
Arthritis, Rheumatoid
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases