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Genetic Analysis of Childhood Obesity (OSV)

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ClinicalTrials.gov Identifier: NCT02326480
Recruitment Status : Recruiting
First Posted : December 29, 2014
Last Update Posted : November 21, 2018
Sponsor:
Collaborator:
Institut Pasteur de Lille
Information provided by (Responsible Party):
Lille Catholic University

Brief Summary:
Identify news genetic causes of different type of obesity (syndromic, familial or isolated obesity) by highlighting new mutations or new implied genes

Condition or disease Intervention/treatment
Obesity Other: Identification of genetic causes of obesity

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Study Type : Observational
Estimated Enrollment : 300 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Genetic Analysis of Childhood Obesity
Study Start Date : January 2015
Estimated Primary Completion Date : December 2020
Estimated Study Completion Date : June 2021

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
Syndromic obesity
Identification of genetic causes of obesity
Familial obesity
Identification of genetic causes of obesity
Other: Identification of genetic causes of obesity
A blood test will be performed to the child and his/her parents with the aim of identifying genetic causes of obesity. Different analysis will be as follows: caryotypes, Raindance, whole exome, in order to find potential mutations or new genes associated to this condition

Isolated obesity
Identification of genetic causes of obesity
Other: Identification of genetic causes of obesity
A blood test will be performed to the child and his/her parents with the aim of identifying genetic causes of obesity. Different analysis will be as follows: caryotypes, Raindance, whole exome, in order to find potential mutations or new genes associated to this condition




Primary Outcome Measures :
  1. To identify the number of mutations or genes involved in genetic causes of Child obesity [ Time Frame: first day of enrollement ]
    Children with obesity and their parents will be recruited to establish genetic causes of obesity. This will allow perform genetic analysis using new approaches for the identification of involved mutations or new candidate genes


Secondary Outcome Measures :
  1. To identify the number of mutations in the population [ Time Frame: first day of enrollement ]
  2. To identify the number of new mutations present in the children's DNA and absent from their parents' genomes [ Time Frame: first day of enrollement ]
    This approach will allow the identification of specific mutations that are present only in affected children but not in their parents

  3. To determine number of phenotypes associated to the child obesity genotype [ Time Frame: first day of enrollement ]

Biospecimen Retention:   Samples With DNA
Blood


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Ages Eligible for Study:   6 Months to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Three categories of obese children with their biological parents will be included (syndromic, familial, isolated obesity).
Criteria

Inclusion criteria:

  • BMI > curve of IOTF 30 (International Obesity Task Force)
  • Age: between 6 months old and 18 years old
  • Child presenting syndromic, isolated or familial obesity.

Exclusion Criteria:

  • Common obesity
  • Impossibility for blood sampling
  • Impossibility to receive information
  • Participation refusal of one of the parents
  • Refusal to sign the informed consent
  • Neither Healthcare coverage nor insurance

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02326480


Contacts
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Contact: Amélie Lansiaux, MD, PhD lansiaux.amelie@ghicl.net
Contact: Mélanie Hamez hamez.melanie@ghicl.net

Locations
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France
Hôpital Saint Vincent de Paul Recruiting
Lille, France
Contact: Louise Montagne         
Sponsors and Collaborators
Lille Catholic University
Institut Pasteur de Lille
Investigators
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Principal Investigator: Louise Montagne Groupement des Hôpitaux de l'Institut Catholique de Lille
Principal Investigator: Philippe Froguel, MD, PhD UMR CNRS 8199, Institut Pasteur de Lille

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Responsible Party: Lille Catholic University
ClinicalTrials.gov Identifier: NCT02326480     History of Changes
Other Study ID Numbers: RC-P0036
First Posted: December 29, 2014    Key Record Dates
Last Update Posted: November 21, 2018
Last Verified: November 2018

Keywords provided by Lille Catholic University:
Childhood Obesity
Genetics

Additional relevant MeSH terms:
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Obesity
Pediatric Obesity
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms