RRI Compared With NephroCheckTM to Predict Acute Renal Failure After Cardiac Surgery.
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|ClinicalTrials.gov Identifier: NCT02325726|
Recruitment Status : Completed
First Posted : December 25, 2014
Last Update Posted : November 2, 2015
Postoperative acute renal failure is a frequent complication after cardiac surgery. The current practice cannot predict Acute Kidney Injuries (AKI) early enough to reduce a significant kidney assault and prevent an organic dysfunction leading to cortical tubular necrosis.
Several recent studies in cardiac surgery have shown that, both sonographic criteria, such as the Renal Resistive Index (IRR) and urinary biomarkers can predict AKI promptly. These urinary biomarkers are the 'tissue inhibitor of metalloproteinases' (TIMP-2) and the 'insulin-like growth factor binding protein' (IGFBP7). These two proteins are sought noninvasively, directly in the urine, within the same test called 'NephroCheckTM'. These markers, ultrasonographic and biologic, have the advantage of being easy to perform, accessible and seem to have both high sensitivity and specificity to predict AKI promptly after cardiac surgery. Thus, the IRR and the NephroCheckTM test could become essential tests to guide clinicians in determining rapidly whether a patient will develop AKI. However, so far, no study has compared these markers yet.
Therefore, the aim of this prospective observational study will be to compare the effectiveness of the IRR with the NephroCheckTM to predict AKI promptly after cardiac surgery. The secondary outcome will be to determine the threshold of these markers from which patients will be likely to develop AKI
|Condition or disease||Intervention/treatment|
|Cardiac Surgery Extracorporeal Circulation Nephrocheck Renal Failure||Procedure: Renal Resistive Index compared with NephroCheckTM|
|Study Type :||Observational|
|Actual Enrollment :||51 participants|
|Official Title:||Renal Resistive Index Compared With NephroCheckTM to Predict Postoperative Acute Renal Failure in Patients Undergoing Cardiac Surgery.|
|Study Start Date :||September 2014|
|Actual Primary Completion Date :||November 2014|
|Actual Study Completion Date :||November 2014|
Renal Resistive Index/Nephrocheck test
Patients undergoing elective cardiac surgery with extracorporeal circulation and who are at risk to develop postoperative Acute Kidney Injury.
Procedure: Renal Resistive Index compared with NephroCheckTM
- Renal Resistive Index compared with NephroCheckTM [ Time Frame: Day 0 (inclusion) / after cardiac surgery ]Compare the effectiveness of the IRR with the NephroCheckTM to predict AKI after cardiac surgery. AKI will be defined according to the RIFLE criteria.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02325726
|CHU de Bordeaux|
|Pessac, Bordeaux, France, 33604|
|Principal Investigator:||Cédrick ZAOUTER, MD||University Hospital, Bordeaux|