Causes of Comorbid Infertility Among Women With Rheumatoid Arthritis
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|ClinicalTrials.gov Identifier: NCT02313129|
Recruitment Status : Completed
First Posted : December 9, 2014
Last Update Posted : May 4, 2017
The purpose of this study is to increase our understanding of infertility in women with Rheumatoid Arthritis (RA). In this study the study team will compare the differences in ovarian reserve (the ability to provide egg cells that are capable of fertilization), the frequency of ovulation and the number of pregnancies between women with and without RA. It is possible that RA activity and medications limit ovarian reserve and ovulation, which may increase infertility among women with RA. There are several suspected causes for infertility in RA, including age-related fertility decline, inflammatory changes that impact endometrial receptivity and discourage implantation, accelerated ovarian decline due to certain arthritis medications and increased frequency of anovulation (a menstrual cycle during which ovaries do not release an egg) due to RA activity.
This study is the first step toward our long term goal of increasing the ability of all women with RA to build the family they desire.
|Condition or disease|
|Infertility Rheumatoid Arthritis|
|Study Type :||Observational|
|Actual Enrollment :||150 participants|
|Official Title:||Causes of Comorbid Infertility Among Women With Rheumatoid Arthritis|
|Study Start Date :||August 2015|
|Actual Primary Completion Date :||January 24, 2017|
|Actual Study Completion Date :||January 24, 2017|
This group will complete questionnaires related to prior pregnancies, intentions and goals for childbearing, fertility history and detailed menstrual history. They will also have a physical exam and blood tests.
This group will complete questionnaires related to prior pregnancies, intentions and goals for childbearing, fertility history detailed menstrual history, and blood tests.
- Ovarian Reserve between women with and without RA [ Time Frame: At study enrollment ]
- Ovulation Frequency between women with and without RA [ Time Frame: At study enrollment ]
- Rates of Infertility between women with and without RA [ Time Frame: At study enrollment ]
- Number of Pregnancies between women with and without RA [ Time Frame: At study enrollment ]
- Age at attempted and actual conception between women with and without RA [ Time Frame: At study enrollment ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02313129
|United States, North Carolina|
|Duke University Medical Center|
|Durham, North Carolina, United States, 27710|
|Principal Investigator:||Megan Clowse, MD||Duke University|