Molecular Analysis of IgE Antibodies in Walnut Allergic Patients
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|ClinicalTrials.gov Identifier: NCT02295267|
Recruitment Status : Completed
First Posted : November 20, 2014
Last Update Posted : May 11, 2017
|Condition or disease||Intervention/treatment||Phase|
|Food Allergy||Other: walnut allergy provocation||Not Applicable|
Accurate diagnosis of food allergy depends on the identification of the causative allergenic molecule(s). Thus, full characterization of the major allergens of walnut and their clinical importance is an important undertaking.
The proposed study intends to investigate and compare the pattern of IgE antibody sensitisation in walnut allergic subjects from three different regions of Europe (south (SEU) and central/north (C/NEU), to evaluate the diagnostic utility of a panel of novel allergen reagents.
With a view towards improved in vitro diagnostic methods, we intend to evaluate the diagnostic potential of recombinant walnut allergens in patients with walnut allergy confirmed by a positive provocation or supported by a convincing history of anaphylactic reaction(s) to walnut in the past, patients with pollinosis but no symptoms of walnut allergy and non-atopic control subjects.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||61 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Molecular Analysis of IgE Antibodies in Walnut Allergic Patients|
|Study Start Date :||December 2012|
|Actual Primary Completion Date :||January 2017|
|Actual Study Completion Date :||March 2017|
Experimental: walnut allergy provocation
inclusion of walnut allergic patients, food provocation with walnut
Other: walnut allergy provocation
double blind placebo controlled food challenge
- numbers of patients with walnut allergy [ Time Frame: December 2012 to November 2017, up to 5 years ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02295267
|Allergy Unit, Department of Dermatology, University Hospital|
|Zürich, Switzerland, 8091|
|Principal Investigator:||Barbara Ballmer-Weber, PI||Allergy Unit, Department of Dermatology, University Zürich|