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Knee Stiffness in Fibrosis Diathesis

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ClinicalTrials.gov Identifier: NCT02294890
Recruitment Status : Unknown
Verified November 2014 by Maarten Van Nuffel, University Hospital Pellenberg.
Recruitment status was:  Not yet recruiting
First Posted : November 19, 2014
Last Update Posted : November 19, 2014
Sponsor:
Information provided by (Responsible Party):
Maarten Van Nuffel, University Hospital Pellenberg

Brief Summary:

At the standard follow-up moment one year after primary TKA for gonarthrosis, all patients will be checked for signs of fibrosis diathesis. This will be done by examining their hands for Dupuytren's nodules and contractures and recording risk factors associated with increased severity and risk of recurrence of Dupuytren's contracture. These include family history, bilateral DD, and ectopic lesions, age of onset less than 50 years, male gender, Ledderhose disease, first ray involvement, multiple ray involvement and ectopic fibromatosis.

This way, two groups of patients will be identified: those with and those without signs of fibrosis diathesis. For both groups, the range of motion (ROM) of the operated knee at 3 and 6 months will be retrieved in the charts, the ROM at 12 months will be measured at that time. Also, additional procedures performed to increase ROM postoperatively will be retrieved from the charts (e.g. continuous passive motion, mobilization under anesthesia). Other causes for knee stiffness will have to be recorded, since these will be the most important exclusion criteria.

In the patients with clear signs of finger contractures, any impression of increase of contracture over the past 12 months will be recorded.


Condition or disease Intervention/treatment
Knee Replacement Arthroplasty Fibrosis Dupuytren's Disease Procedure: Total knee arthroplasty

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Study Type : Observational
Estimated Enrollment : 60 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Does Fibrosis Diathesis Influence the Recovery of Knee Mobility After Total Knee Replacement?
Study Start Date : January 2015
Estimated Primary Completion Date : March 2015
Estimated Study Completion Date : April 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Knee Replacement

Group/Cohort Intervention/treatment
Fibrosis diathesis

all patients will be checked for signs of fibrosis diathesis. This will be done by examining their hands for Dupuytren's nodules and contractures and recording risk factors associated with increased severity and risk of recurrence of Dupuytren's contracture. These include family history, bilateral DD, and ectopic lesions, age of onset less than 50 years, male gender, Ledderhose disease, first ray involvement, multiple ray involvement and ectopic fibromatosis.

This way, two groups of patients will be identified: those with and those without signs of fibrosis diathesis.

Procedure: Total knee arthroplasty
No fibrosis diathesis

all patients will be checked for signs of fibrosis diathesis. This will be done by examining their hands for Dupuytren's nodules and contractures and recording risk factors associated with increased severity and risk of recurrence of Dupuytren's contracture. These include family history, bilateral DD, and ectopic lesions, age of onset less than 50 years, male gender, Ledderhose disease, first ray involvement, multiple ray involvement and ectopic fibromatosis.

This way, two groups of patients will be identified: those with and those without signs of fibrosis diathesis.

Procedure: Total knee arthroplasty



Primary Outcome Measures :
  1. Range of movement of the operated knee at 12 months postoperatively [ Time Frame: 12 months ]
  2. Additional procedures/interventions to gain motion [ Time Frame: 12 months ]

Secondary Outcome Measures :
  1. - Increase of contracture or appearance of the nodules and contractures in the hand after the knee surgery. [ Time Frame: 12 months ]
  2. KSS score for knee function [ Time Frame: 12 months ]


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Ages Eligible for Study:   50 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All patients who undergo a total knee arthroplasty for primary gonarthrosis at a minimal age of 50 years showing signs of fibrosis diathesis at presentation can be included. Patients who do not show signs of fibrosis diathesis will serve as a control group.
Criteria

Inclusion Criteria:

  • All patients undergoing a total knee replacement for primary gonarthrosis with a minimum follow-up of 1 year

Exclusion Criteria:

  • Patients undergoing a TKA for other reasons than primary gonarthrosis, e.g. after infection, posttraumatic arthritis,hemophilia,…
  • Patients who had other problems after their TKA resulting in knee stiffness, e.g. infection, bleeding,…

Publications:
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Responsible Party: Maarten Van Nuffel, Fellow, University Hospital Pellenberg
ClinicalTrials.gov Identifier: NCT02294890     History of Changes
Other Study ID Numbers: UHPellenberg
First Posted: November 19, 2014    Key Record Dates
Last Update Posted: November 19, 2014
Last Verified: November 2014

Additional relevant MeSH terms:
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Dupuytren Contracture
Fibrosis
Pathologic Processes
Fibroma
Neoplasms, Fibrous Tissue
Neoplasms, Connective Tissue
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Neoplasms
Contracture
Muscular Diseases
Musculoskeletal Diseases
Connective Tissue Diseases