Maternal Microchimerism in Lymph Nodes of Infants With Biliary Atresia at Time of Kasai's Operation (K-LNMC)
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|ClinicalTrials.gov Identifier: NCT02292862|
Recruitment Status : Completed
First Posted : November 17, 2014
Last Update Posted : November 17, 2014
Maternal microchimerism has been discussed as an etiological mechanism in infantile (perinatal) biliary atresia (BA). In Kasai's operation (resection of the liver hilum plaque followed by hepato-portoenterostomy) surgeons frequently encounter swollen portal and mesenteric lymph nodes.
Lymph nodes were sampled during Kasai' s operation and examined for maternal DNA.
|Condition or disease||Intervention/treatment|
|Biliary Atresia||Procedure: Lymph node and blood sampling|
Show Detailed Description
|Study Type :||Observational|
|Actual Enrollment :||7 participants|
|Observational Model:||Case Control|
|Official Title:||Search for Maternal Microchimerism in Swollen Portal Lymph Nodes of Infants With Biliary Atresia.|
|Study Start Date :||November 2012|
|Actual Primary Completion Date :||November 2013|
|Actual Study Completion Date :||November 2014|
MG Main Group
lymph node and blood sampling
Procedure: Lymph node and blood sampling
By bipolar dissection 1 portal and 1 mesenteric lymph node are removed from the infant.
Blood (1ml) is taken from mother and infant.
- Maternal DNA in offspring [ Time Frame: 3 months ]The presence of maternal DNA in the childs blood and lymph nodes is the endpoint
- Serum Bilirubin [ Time Frame: perioperatively ]
- Composition of lymphocyte population in mesenteric lymph nodes [ Time Frame: 3 months ]
Biospecimen Retention: Samples With DNA
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02292862
|Pediatric Surgery Department|
|Hannover, Lower Saxony, Germany, 30625|
|Principal Investigator:||Carsten R Engelmann, MD, OhD||Klinikum Brandenburg|