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Minority Health Genomics and Translational Research Bio-Repository Database (MH-GRID)-2.0

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ClinicalTrials.gov Identifier: NCT02290392
Recruitment Status : Completed
First Posted : November 14, 2014
Last Update Posted : August 12, 2019
Sponsor:
Collaborator:
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Human Genome Research Institute (NHGRI) )

Brief Summary:

Background:

- High blood pressure is a common problem. It can cause heart attacks, strokes, and kidney failure. It affects African Americans more than other racial groups. Data were collected from over a thousand African Americans across the country. The data were put into a database (MH-GRID). The data were about genes, diet, sleep, body mass index. They also cover stress and access to healthy foods and parks. Researchers at NIH will study these data in new ways. They want to learn more about the connection between African Americans and high blood pressure.

Objective:

- To study MH-GRID data to find the causes of severe high blood pressure and other cardio-metabolic problems in people of African ancestry.

Eligibility:

- African Americans age 30 55 with severe high blood pressure were used in the MH-GRID study. No new participants will be enrolled in this study.

Design:

- Researchers will examine data from the MH-GRID study.


Condition or disease
Hypertension

Detailed Description:

The etiology of racial/ethnic differences in health involves dynamic interactions between

genetic, behavioral and social-environmental determinants. Despite this, the field lacks robust

datasets that integrate these determinants with clinical assessments in minority patient cohorts. The Minority Health Genomics and Translational Research Bio-repository Database (MHGRID) Network infrastructure facilitated the collection of biospecimens and related multidimensional data elements within a consortium of minority-serving clinics. This initiative expands the diversity of ancestral groups in national genomic medicine datasets and promises to accelerate the translation of personalized medicine into minority communities. The MH-GRID project was initiated by Dr. Gibbons (founding PI) prior to becoming an NIH investigator. The MH-GRID project has completed its participant recruitment activities, closed out its NIH funding and now represents an existing dataset and biorepository that is being transferred to NHGRI for ongoing secondary analyses. A variety of investigations will be conducted on this existing dataset. The primary outcome variables include severe hypertension and hypertension induced kidney damage. Secondary outcome variables include obesity, coronary heart disease and metabolic disease syndrome. Intervening variables include genetics, behavioral (i.e. sleep quality, health literacy, smoking, diet, body mass index), ancestry, social (i.e. socioeconomic status, racial discrimination, stress, social depreivation), biological (i.e. insulin resistance, cholesterol, inflammatory markers), and environmental (i.e. neighborhood, access to healthy foods, parks).


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Study Type : Observational
Actual Enrollment : 1692 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: The Minority Health Genomics and Translational Research BIo-Repository Database (MH-GRID)-2.0
Study Start Date : November 11, 2014
Actual Primary Completion Date : July 16, 2019
Actual Study Completion Date : July 16, 2019

Resource links provided by the National Library of Medicine


Group/Cohort
1
African Americans age 30-55 years with severe controlled HTN or severe resistant HTN.



Primary Outcome Measures :
  1. To complete the original MHGRID primary outcome analyses by defining the genetic, behavioral , and social-environmental determinants of severe hypertension and other cardiometabolic disorders in individuals of African ancestry. [ Time Frame: one time analysis ]
    To complete the original MH-GRID primary outcome analyses by defining the genetic, behavioral , and social-environmental determinants of severe hypertension and other cardio- metabolic disorders in individuals of African ancestry.


Secondary Outcome Measures :
  1. The secondary outcome variables include obesity, coronary heart disease and metabolic disease syndrome. Intervening variables include genetics, behavioral, ancestry, social, biological, and environmental. [ Time Frame: one time analysis ]
    The secondary outcome variables include obesity, coronary heart disease and metabolic disease syndrome. Intervening variables includegenetics, behavioral, ancestry, social, biological, and environmental.



Information from the National Library of Medicine

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Ages Eligible for Study:   30 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Criteria
  • INCLUSION CRITERIA:
  • The MH-GRID Project s inclusion criteria included AA age 30-55 years
  • Severe controlled HTN or severe resistant HTN.

EXCLUSION CRITERIA:

  • Exclusion criteria involved patients with secondary forms of HTN, primary forms of kidney disease or major co-morbidities (e.g. diabetes, heart failure, end-stage renal failure, HIV, and liver disease).
  • Children <18 were not enrolled in the protocol.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02290392


Locations
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United States, Maryland
National Human Genome Research Institute (NHGRI), 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Human Genome Research Institute (NHGRI)
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
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Principal Investigator: Gary H Gibbons, M.D. National Heart, Lung, and Blood Institute (NHLBI)

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Responsible Party: National Human Genome Research Institute (NHGRI)
ClinicalTrials.gov Identifier: NCT02290392     History of Changes
Other Study ID Numbers: 999915011
15-HG-N011
First Posted: November 14, 2014    Key Record Dates
Last Update Posted: August 12, 2019
Last Verified: August 7, 2019

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Studies a U.S. FDA-regulated Device Product: No
Keywords provided by National Institutes of Health Clinical Center (CC) ( National Human Genome Research Institute (NHGRI) ):
African American
Additional relevant MeSH terms:
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Hypertension
Vascular Diseases
Cardiovascular Diseases