Enhanced Diagnostics for Early Detection of Atrial Fibrillation (DETECT-AF)
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|ClinicalTrials.gov Identifier: NCT02270112|
Recruitment Status : Completed
First Posted : October 21, 2014
Last Update Posted : December 14, 2017
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Paroxysmal atrial fibrillation can only be diagnosed during episodes when the arrhythmia is present.
The investigators hypothesize that the activation of the atrial myocardium resulting in the p-wave of the ecg should display abnormalities in diseased atria which are vulnerable for AF.
|Condition or disease||Intervention/treatment|
|Atrial Fibrillation||Device: ECG|
In the first part of this trial different diagnostic techniques to detect arrythmogenic substrates of atrial fibrillation will be tested. If suitable parameters can be identified, a follow up trial to identify patients at risk for AF will be conducted before a stroke happens.
Parameters tested are
- Electrophysiological differences between patients with paroxysmal AF and no history of AF
- "Vascular Stiffness" detected by an iPhone app
All patients will undergo a cardiogoniometrie and a pulse wave analysis with an iPhone. Each exam takes 5 minutes.
|Study Type :||Observational [Patient Registry]|
|Actual Enrollment :||287 participants|
|Target Follow-Up Duration:||1 Day|
|Official Title:||Enhanced Diagnostics for Early Detection of Atrial Fibrillation - DETECT AF Trial|
|Study Start Date :||June 2014|
|Actual Primary Completion Date :||October 2015|
|Actual Study Completion Date :||October 2015|
No Intervention is planned. All patients receive a 5 Minute ECG and have their pulse recordes by an iPhone.
Patients receive a 5 Minute ECG recording and have their pulse recorded by an iPhone.
- Beat to beat variation of the electrical activation vector of the atrium [ Time Frame: Once during the exam (baseline) - No further follow up planned ]Test if the beat to beat Variation of the electrical activation of the atrium differentiates between the group of patients with paroxysmal AF and no AF in history.
- Averaged slope of pressure-curve [ Time Frame: Once during exam (5min, baseline) - No further follow up planned ]Test if the steepness of the slope of the pressure curve recorded with the iPhone differs between the two Groups.
- Averaged slope of pressure-curve [ Time Frame: Once during exam (5min, baseline) - No further follow up planned ]Test if the steepness of the slope of the pressure curve recorded with the iPhone correlates with cardiovascular risk factors.
- Heart rate variability [ Time Frame: Once during exam (5min, baseline) - No further follow up planned ]Test if heart rate variability recorded with the iPhone differs between the two Groups.
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|Ages Eligible for Study:||18 Years and older (Adult, Older Adult)|
|Sexes Eligible for Study:||All|
|Accepts Healthy Volunteers:||Yes|
|Sampling Method:||Non-Probability Sample|
- paroxysmal atrial fibrillation in sinus rhythm at presentation
- acute cerebral trauma
- antiarrhythmic medication
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02270112
|University Hospital Basel|
|Basel, BS, Switzerland, 4031|
|Principal Investigator:||Jens Eckstein, MD, PhD||Universityhospital Basel|
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:||Jens Eckstein, MD, PhD, University Hospital, Basel, Switzerland|
|Other Study ID Numbers:||
|First Posted:||October 21, 2014 Key Record Dates|
|Last Update Posted:||December 14, 2017|
|Last Verified:||December 2017|