Examination of the Pathophysiologic Mechanisms of CRPS by Using QST, CPM, RIC, and Heart Rate Variability QST
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|ClinicalTrials.gov Identifier: NCT02261012|
Recruitment Status : Completed
First Posted : October 9, 2014
Last Update Posted : February 9, 2016
|Condition or disease|
|Complex Regional Pain Syndrome Carpal Tunnel Syndrome Neuralgia|
CRPS is an illness which (seriously) affects patients in their daily life activity. The fact that the pathophysiological mechanisms are not well understood yet makes it hard to treat these patients in the right manner.
Possible patho-mechanisms might be microvascular changes and dysfunctions of the inhibitory descending pain system. Furthermore, recent studies showed that CRPS patients have macrovascular changes and a lower blood level of NO on the affected side. This indicates a NO mediated perfusion dysfunction.
Aim of this study is to examine the pathophysiological mechanism of CRPS in relation to healthy subjects and patients with a different type of pain syndrome (carpal tunnel syndrome) on the upper limb.
The investigators try to get a better understanding of the changes in the pain inhibitory system and micro- and macrocirculating blood-systems, as well as of the autonomic system of CRPS-patients.
|Study Type :||Observational|
|Actual Enrollment :||62 participants|
|Observational Model:||Case Control|
|Official Title:||Examination of the Pathological Mechanism of the Complex Regional Pain Syndrome of the Upper Limb in Comparison to Patients With Painful Carpal Tunnel Syndrome and Healthy Subjects - an Explorative Clinical Study|
|Study Start Date :||April 2014|
|Actual Primary Completion Date :||April 2015|
|Actual Study Completion Date :||August 2015|
30 healthy probands
group without the condition of interest
30 CRPS patients
group with condition of interest
30 CTS patients
group with a different type of pain on the upper limbs
- CPM effect [ Time Frame: 60 seconds ]Conditioned Pain Modulation measured by the Heat-Cold-Pain Method
- Remote Ischemic Conditioning [ Time Frame: 45 minutes ]the perfusion increasing effect after RIC in all groups
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02261012
|Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH|
|Bochum, Nordrhein-Westfalen, Germany, 44789|
|Principal Investigator:||Tina Mainka, Dr. med.||University Hospital Bergmannsheil, Department of Pain Medicine|