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Association of Previously Verified Gene Polymorphisms With AMD in Turkish Population (AMD-SNP)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02248324
Recruitment Status : Unknown
Verified August 2016 by Umit Ubeyt INAN, Kocatepe University.
Recruitment status was:  Recruiting
First Posted : September 25, 2014
Last Update Posted : August 30, 2016
The Scientific and Technological Research Council of Turkey
Information provided by (Responsible Party):
Umit Ubeyt INAN, Kocatepe University

Brief Summary:
The purpose of this study is to determine whether common genetic polymorphisms that have been verified to be related to age-related macular degeneration (AMD) in some populations are also associated with AMD in Turkish population

Condition or disease
Age-related Macular Degeneration

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Study Type : Observational
Estimated Enrollment : 5000 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: A Multicenter Study on the Investigation of Previously Verified Leading Gene Polymorphisms Related to Age-related Macular Degeneration in Turkish Population
Study Start Date : November 2012
Estimated Primary Completion Date : December 2016
Estimated Study Completion Date : November 2017

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. rate of homozygous, heterozygous or wild type genotype and allels [ Time Frame: at the end of third years ]
    Gene polymorphisms of 8 region with identification of homozygous, heterozygote and wild type genotyping and alleles

Secondary Outcome Measures :
  1. Odds ratios for each genotyping in healthy elderly controls and patients with age related macular degeneration [ Time Frame: at the end of third years ]

Other Outcome Measures:
  1. Odds ratios for various combinations of gene regions between healthy elderly control and patients with age related macular degeneration [ Time Frame: at the end of third years ]

Biospecimen Retention:   Samples With DNA
Whole blood

Information from the National Library of Medicine

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Ages Eligible for Study:   60 Years to 100 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients with intermediate and advanced age related macular degeneration

Inclusion Criteria:

  • Older age more than 50 years for the study group and older age more than 60 years for the control group
  • Intermediate or advanced stage age-related macular degeneration
  • Active or inactive scar choroidal neovascularization
  • For control patients: Normal macular anatomy and no sign of any stage of age-related macular degeneration

Exclusion Criteria:

  • People with findings of advanced age-related macular degeneration due to other reasons (inflammatory, myopic choroidal neovascularization etc..)
  • For control patients: Any sign of age-related macular degeneration

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02248324

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Contact: Umit U INAN, MD +902722140600
Contact: Handan Yildizus, PhD +905055044162

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Umit Ubeyt INAN Recruiting
Afyonkarahisar, Afyon, Turkey, 03200
Contact: Umit U Inan, MD    +905323248889   
Contact: Handan YILDIZ, PhD    +905055044162   
Principal Investigator: Umit U INAN, MD         
Principal Investigator: Handan YILDIZUS, PhD         
Principal Investigator: Nilufer KOCAK, MD         
Principal Investigator: Banu OZTURK, MD         
Principal Investigator: Hurkan KERIMOGLU, MD         
Principal Investigator: Mujgan OZDEMIR, PhD         
Principal Investigator: Berkant KADERLI, MD         
Principal Investigator: Ozgur YALCINBAYIR, MD         
Principal Investigator: Mustafa DOGAN, MD         
Principal Investigator: Remzi AVCI, MD         
Principal Investigator: Suleyman KAYNAK, MD         
Principal Investigator: Suleyman DUNDAR, PhD         
Sponsors and Collaborators
Kocatepe University
The Scientific and Technological Research Council of Turkey
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Study Chair: Umit U INAN, MD Kocatepe University Medical School Department of Ophthalmology
Publications of Results:
Sofat R, Casas JP, Webster AR, Bird AC, Mann SS, Yates JR, Moore AT, Sepp T, Cipriani V, Bunce C, Khan JC, Shahid H, Swaroop A, Abecasis G, Branham KE, Zareparsi S, Bergen AA, Klaver CC, Baas DC, Zhang K, Chen Y, Gibbs D, Weber BH, Keilhauer CN, Fritsche LG, Lotery A, Cree AJ, Griffiths HL, Bhattacharya SS, Chen LL, Jenkins SA, Peto T, Lathrop M, Leveillard T, Gorin MB, Weeks DE, Ortube MC, Ferrell RE, Jakobsdottir J, Conley YP, Rahu M, Seland JH, Soubrane G, Topouzis F, Vioque J, Tomazzoli L, Young I, Whittaker J, Chakravarthy U, de Jong PT, Smeeth L, Fletcher A, Hingorani AD. Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype. Int J Epidemiol. 2012 Feb;41(1):250-62. doi: 10.1093/ije/dyr204. Epub 2012 Jan 13.

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Responsible Party: Umit Ubeyt INAN, Professor Doctor, Kocatepe University Identifier: NCT02248324    
Other Study ID Numbers: 0112S269
First Posted: September 25, 2014    Key Record Dates
Last Update Posted: August 30, 2016
Last Verified: August 2016
Keywords provided by Umit Ubeyt INAN, Kocatepe University:
Age-related macular degeneration, genetic polymorphisms
Additional relevant MeSH terms:
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Macular Degeneration
Retinal Degeneration
Retinal Diseases
Eye Diseases