Efficacy of Low-dose Dexmedetomidine to Prevent Delirium in Liver Transplant Patients
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|ClinicalTrials.gov Identifier: NCT02245256|
Recruitment Status : Recruiting
First Posted : September 19, 2014
Last Update Posted : January 25, 2018
To test the effect of low-dose dexmedetomidine for lowering the incidence of postoperative delirium in liver transplant patients in the ICU.
Single center prospective randomized placebo controlled clinical trial 0.1mcg/kg/hr of dexmedetomidine or equivalent amount of saline infusion started after induction of anesthesia for liver transplantation and continued until 48 hours after surgery.
Outcomes will be assessed up to 1 week or transfer to ward, whichever comes first.
|Condition or disease||Intervention/treatment||Phase|
|Liver Transplantation||Drug: Precedex Drug: placebo control||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||210 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Official Title:||Perioperative Low-dose Dexmedetomidine Decreases Incidence of Delirium in Liver Transplant Patients|
|Actual Study Start Date :||September 2014|
|Actual Primary Completion Date :||January 2018|
|Estimated Study Completion Date :||April 2018|
Placebo Comparator: Normal saline
same infusion rate as experimental group (dexmedetomidine)
Drug: placebo control
Other Name: 0.9% saline
0.1mcg/kg/hr of dexmedetomidine infusion started after induction of anesthesia for liver transplantation and continued until 48 hours after surgery.
infusion of 0.1mcg/kg/hr of precedex
- analysis of the incidence of postoperative delirium in liver transplant patients in the ICU. [ Time Frame: 1 week or transfer to ward, whichever comes first. ]after August 25, 2014
- analysis of the duration of postoperative delirium, ICU length of stay in liver transplant patients in the ICU. [ Time Frame: 1 week or transfer to ward, whichever comes first. ]after August 26, 2014
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02245256
|Contact: Hogeol Ryu, MD, PhDemail@example.com|
|Contact: Hannah Lee, MDfirstname.lastname@example.org|
|Korea, Republic of|
|Seoul National University Hospital||Recruiting|
|Seoul, Agree, Korea, Republic of, 110-744|
|Contact: Hogeol Ryu, MD, PhD 82-2-2072-2469 email@example.com|
|Contact: Hannah Lee, MD 82-2-2072-3538 firstname.lastname@example.org|
|Principal Investigator: Hogeol Ryu, MD, PhD|
|Principal Investigator:||Hogeol Ryu, MD, PhD||Seoul National University Hospital|