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A Study of Obinutuzumab(GA101) in Combination With High-Dose Methylprednisolone(HDMP) in Chronic Lymphocytic Leukemia(CLL) Patients (GA101 & HDMP) (GA101 & HDMP)

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ClinicalTrials.gov Identifier: NCT02229422
Recruitment Status : Recruiting
First Posted : September 1, 2014
Last Update Posted : May 24, 2016
Sponsor:
Collaborator:
Information provided by (Responsible Party):

Study Description
Brief Summary:
We hypothesize that GA101 - Obinutuzumab in combination with HDMP is well tolerated and will induce similar if not higher response rates than the ones observed in Rituximab plus HDMP studies (Castro et al., 2009, Castro et al., 2008).

Condition or disease Intervention/treatment Phase
CLL Drug: GA101/HDMP Phase 1 Phase 2

Detailed Description:
This is an open label phase Ib/II clinical trial to determine the safety and clinical activity of the GA101 - Obinutuzumab in combination with high-dose methylprednisone (HDMP). We will evaluate dose-limiting toxicities (DLTs) during the first month of therapy as part of the phase Ib of this study. In the phase II we will determine response rate in an intention to treat analysis. In this study we will include CLL patients that have never received treatment as well as patients that have failed previous treatments.

Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Study of Obinutuzumab in Combination With High-Dose Methylprednisolone in Chronic Lymphocytic Leukemia Patients
Study Start Date : September 2014
Estimated Primary Completion Date : May 2016
Estimated Study Completion Date : May 2017


Arms and Interventions

Arm Intervention/treatment
Experimental: GA101/HDMP

All subjects will receive GA101 - Obinutuzumab by IV infusion for up to 6 cycles (28-day cycles) as follow:

  • On Cycle 1, Day 1, 100 mg GA101-obinutuzumab will be administered.
  • On Cycle 1, Day 2, 900 mg of GA101-obinutuzumab will be administered.
  • On Cycle 1, Days 8 and 15, 1,000 mg of GA101-obinutuzumab will be administered.
  • On Cycles 2-6, Day 1, 1,000 mg of GA101-obinutuzumab will be administered.

All subjects will receive HDMP by IV infusion for up to 4 cycles (28-day cycles) as follow:

•On Cycle 1-4, Days 1 to 3, 1,000 mg/m2 Methylprednisolone will be administered.

Drug: GA101/HDMP

All subjects will receive GA101 - Obinutuzumab by IV infusion for up to 6 cycles (28-day cycles) as follow:

  • On Cycle 1, Day 1, 100 mg GA101-obinutuzumab will be administered.
  • On Cycle 1, Day 2, 900 mg of GA101-obinutuzumab will be administered.
  • On Cycle 1, Days 8 and 15, 1,000 mg of GA101-obinutuzumab will be administered.
  • On Cycles 2-6, Day 1, 1,000 mg of GA101-obinutuzumab will be administered.

All subjects will receive HDMP by IV infusion for up to 4 cycles (28-day cycles) as follow:

•On Cycle 1-4, Days 1 to 3, 1,000 mg/m2 Methylprednisolone will be administered.



Outcome Measures

Primary Outcome Measures :
  1. Adverse events that constitute the Dose Limiting Toxicity [ Time Frame: 2 months ]
  2. Response assessment based on IWCLL [ Time Frame: 2 months ]

Secondary Outcome Measures :
  1. Progression Free Survival [ Time Frame: 2 years ]
  2. Overall Survival and Minimal residual disease (MRD) [ Time Frame: 2 years ]

Eligibility Criteria

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Diagnosis of CLL
  2. Indication for treatment as defined by the IWCLL Guidelines (Hallek et al., 2008b).
  3. Males and females 18 years of age and older.
  4. Laboratory parameters as specified below:

    • Hematologic: Hemoglobin > 8 g/dL (may be post-transfusion); platelet count > 40 x103/mm3 (may be post-transfusion). Absolute neutrophil count > 1.0 109 cells/mm3 (Growth factor use is allowed).
    • Hepatic: Total Bilirubin < 3 x ULN, and ALT and AST < 3 x ULN
    • Renal: Creatinine clearance > 30 mL/min (Calculated according to institutional standards or using Cockcroft-Gault formula. Subjects with requirement of hemodialysis will be excluded).
  5. ECOG Performance Status < 2, unless the decline of the performance status is considered to be related to CLL symptoms.
  6. Anticipated survival of at least 6 months.
  7. Subjects can be enrolled and treated under this protocol regardless of their CLL treatment history or number of previous treatments. In addition, subjects with history of allogeneic stem cell transplant can be enrolled and treated unless they have active manifestations of graft vs. host disease (GVHD) or chronic illness or infections that will prevent them from completing the study.
  8. Previously untreated subjects that meet ANY of the following criteria: A. Documented refusal to be treated with chemotherapy agents. B. Subjects that are not candidates for treatment with chemotherapy based on poor performance status (ECOG ≥ 2), advance age (> 65 years), Cumulative Illness Rating Scale (CIRS score) ≥ 6 or cytopenias.
  9. Effective contraception is required while receiving GA101 - Obinutuzumab. For women of childbearing potential and men, effective contraception is required while receiving GA101 - Obinutuzumab and for 365 days (12 months) after the last dose of the study drug.
  10. Ability to understand the requirements of the study, provide written informed consent and authorization of use and disclosure of protected health information, and agree to abide by the study restrictions and return for the required assessments.
  11. Subjects must give written informed consent to participate in this trial.

Exclusion Criteria:

  1. Pregnant or nursing women.
  2. Treatment with chemotherapy, monoclonal antibodies or biological agents (e.g. Ibrutinib, lenalidomide) within 28 days prior to entering the study.
  3. Treatment with chemotherapy, monoclonal antibodies, biological agents (e.g. Ibrutinib) or other than the investigational agents during the time of participation in this trial.
  4. Grade 3 or 4 cardiac disease as defined by the New York Heart Association Functional Classification.
  5. Severe or debilitating pulmonary disease (dyspnea at rest, significant shortness of breath, COPD)
  6. Participation in any investigational drug study within 28 days prior to initiation of treatment within this protocol.
  7. History of second malignancy, other than non-melanoma skin cancer or in situ carcinoma of the cervix or the breast, unless the tumor was successfully treated at least 2 years before trial entry and with no evidence of relapse or active cancer.
  8. Active symptomatic fungal, bacterial and/or viral infection including evidence of infection with HIV, human T-cell leukemia virus 1 (HTLV-1) seropositive status.
  9. Evidence of active acute or chronic Hepatitis B (HBV).
  10. Evidence of active Hepatitis C (HCV): subjects with positive hepatitis C serology AND positive HCV RNA test.
  11. Any illness or condition that in the opinion of the Investigator may affect safety of treatment or evaluation of any the study's endpoints.
  12. History of severe allergic or anaphylactic reactions to monoclonal antibody therapy
  13. Known hypersensitivity to any of the study drugs.
  14. Major surgery (within 4 weeks prior to the start of Cycle 1), except for procedures that are performed for diagnostic purposes.
  15. Men or women of childbearing potential who refuse to use an adequate measure of contraception (oral contraceptives, intrauterine device, or barrier method of contraception in conjunction with spermicidal jelly) unless they have past medical history of surgical sterilization.
  16. Vaccination with a live vaccine within 28 days of the initiation of treatment.
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02229422


Contacts
Contact: Kipps J. Thomas, M.D.,Ph.D. 858-534-5400 tkipps@ucsd.edu

Locations
United States, California
UCSD Moores Cancer Center Recruiting
La Jolla, California, United States, 92093
Sponsors and Collaborators
University of California, San Diego
Genentech, Inc.
Investigators
Principal Investigator: Kipps Thomas, MD University of California, San Diego
More Information

Responsible Party: Thomas Kipps, Associate Clinical Professor, University of California, San Diego
ClinicalTrials.gov Identifier: NCT02229422     History of Changes
Other Study ID Numbers: 140396
First Posted: September 1, 2014    Key Record Dates
Last Update Posted: May 24, 2016
Last Verified: May 2016

Additional relevant MeSH terms:
Leukemia, Lymphoid
Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia
Neoplasms by Histologic Type
Neoplasms
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Leukemia, B-Cell
Prednisolone acetate
Methylprednisolone acetate
Methylprednisolone
Methylprednisolone Hemisuccinate
Prednisolone
Prednisolone hemisuccinate
Prednisolone phosphate
Obinutuzumab
Anti-Inflammatory Agents
Antiemetics
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Gastrointestinal Agents
Glucocorticoids
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Neuroprotective Agents
Protective Agents
Antineoplastic Agents, Hormonal