Prediction of Fluid Responsiveness in Atrial Fibrillation Patients Who Underwent Valvular Heart Surgery: Peep-induced Increase in Central Venous Pressure vs. Passive Leg Raising
Dynamic indices of preload depending on the heart-lung interaction require sinus rhythm and cannot be applied to patients with atrial fibrillation. PEEP-induced increase in central venous pressure (CVP) was shown to be a valid predictor of fluid responsiveness after cardiac surgery in patients with sinus rhythm, and was speculated to be of value in patients with rhythm other than sinus. The aim of this study is to assess the predictability of PEEP-induced increase in CVP and passive leg raising (PLR)-induced changes in stroke volume index (SVI) on fluid responsiveness in patients with atrial fibrillation following valvular heart surgery.
Valvular Heart Surgery
Procedure: peep induced CVP
Procedure: passive leg raising(PLR)
|Study Design:||Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Diagnostic
- fluid responsiveness [ Time Frame: 1hr after arriving at ICU ] [ Designated as safety issue: No ]
- ventilator peep setting was adjusted to 0cmH2O as baseline
- Then peep was increased to 10cmH2O for 5 min.
- We set peep to baseline 0cmH2O again, making patients to semirecumbent position following passive leg raising at 30 degree for 5 min.
- After that, 300 ml of hydroxyethyl starch 130/0.4 was infused in the supine position for 10-20 min and haemodynamic variables including SVI were assessed 5 min after completion of fluid challenge.
|Study Start Date:||March 2012|
|Study Completion Date:||October 2014|
|Primary Completion Date:||October 2014 (Final data collection date for primary outcome measure)|
|Experimental: peep induced CVP||Procedure: peep induced CVP|
|Active Comparator: passive leg raising(PLR)||Procedure: passive leg raising(PLR)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT02224378
|Korea, Republic of|
|Department of Anesthesiology & Pain Medicine, Yonsei university college of medicine|
|Seoul, Korea, Republic of, 120-752|