The Improvement of Limbal Epithelial Culture Technique by Using Collagenase to Isolate Limbal Stem Cells
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|ClinicalTrials.gov Identifier: NCT02202642|
Recruitment Status : Unknown
Verified July 2014 by National Taiwan University Hospital.
Recruitment status was: Recruiting
First Posted : July 29, 2014
Last Update Posted : July 29, 2014
|Condition or disease||Intervention/treatment||Phase|
|Alkaline Chemical Burn Of Cornea And Conjunctival Sac Acid Chemical Burn Of Cornea And Conjunctival Sac Benign Mucous Membrane Pemphigoid With Ocular Involvement||Procedure: collagenase||Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||10 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||The Improvement of Limbal Epithelial Culture Technique for the Treatment of Unilateral Limbal Insufficiency by Using Collagenase to Isolate Limbal Stem Cells|
|Study Start Date :||January 2012|
|Estimated Primary Completion Date :||December 2015|
|Estimated Study Completion Date :||December 2015|
Experimental: limbal stem cells
Using collagenase to isolate limbal stem cells and improve the technique of ex vivo expansion of limbal stem cells for the treatment of patients suffering from unilateral limbal stem cell insufficiency based on the concept of "limbal stem cells need special cell-cell contact and cell-extracellular matrix interaction to support their survival"
Cultured limbal stem cells transplantation
- Using collagenase to isolate limbal stem cells and improve the technique of ex vivo expansion of limbal stem cells for the treatment. [ Time Frame: 12 months ]Nine to twelve days later after successful culture, transplantation will be performed after the cells diameter reaches 1.5-2.0 cm compact confluent epithelial sheets without evidence of contamination.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02202642
|Contact: Wei Li Chen, MD, PhD||886-2-23123456 ext email@example.com|
|Taipei, Taiwan, 100|
|Principal Investigator:||Wei Li Chen, MD, PhD||National Taiwan University Hospital|