Basic Research Study to Examine the Relation Between Muscle Insulin Resistance and Lipid Production in the Liver.
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|ClinicalTrials.gov Identifier: NCT02196051|
Recruitment Status : Completed
First Posted : July 21, 2014
Last Update Posted : May 5, 2022
|Condition or disease||Intervention/treatment||Phase|
|Insulin Resistance||Other: Exercise Training||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||41 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Lipid and Carbohydrate Metabolism: Effects of Exercise|
|Actual Study Start Date :||January 1, 2017|
|Actual Primary Completion Date :||June 29, 2020|
|Actual Study Completion Date :||June 29, 2020|
Experimental: Exercise Training
Participants will engage in a single bout of elliptical exercise for 45 minutes (3X15 spaced by 5 minutes rest) at baseline. Subjects will be studied before and after this one bout to measure hepatic de novo lipogenesis. Participants will then take part in six weeks of exercise training on an elliptical trainer 3 times per week each time for 45 minutes. Hepatic de novo lipogenesis will be compared pre and post to examine wether improving muscle glucose uptake will decrease hepatic de novo lipogenesis as the glucose is taken up by muscle and not directed to the liver.
Other: Exercise Training
Six weeks of exercise
- change in de novo lipogenesis [ Time Frame: Baseline ]At the baseline assessment, de novo lipogenesis will be assessed by giving a high carbohydrate meal and heavy water to drink. Muscle glycogen and lipid contents pre- and post meal will be measured using 1H/13C MRS and de novo lipogenesis will be assessed from the heavy water incorporation into blood lipid in samples collected overnight.
- change in de novo lipogenesis [ Time Frame: 6 weeks ]At the 6 weeks assessment, de novo lipogenesis will be assessed by giving a high carbohydrate meal and heavy water to drink. Muscle glycogen and lipid contents pre- and post meal will be measured using 1H/13C MRS and de novo lipogenesis will be assessed from the heavy water incorporation into blood lipid in samples collected overnight.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02196051
|United States, Connecticut|
|YCCI/YNNH Hospital Research Unit|
|New Haven, Connecticut, United States, 06520|
|Principal Investigator:||Kitt Petersen, MD||Yale University|