The Function of Cricothyroid Muscle and Its Impaction on Mandarin Lexical Tones in Unilateral Vocal Fold Paralysis
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|ClinicalTrials.gov Identifier: NCT02184377|
Recruitment Status : Unknown
Verified July 2014 by Fang Tuan-Jen, Chang Gung Memorial Hospital.
Recruitment status was: Enrolling by invitation
First Posted : July 9, 2014
Last Update Posted : July 9, 2014
|Condition or disease|
|Unilateral Vocal Cord Paralysis|
Purposes: 1. Searching for a standard task to measure CT function by Q-LEMG. 2. Correlate the data among Q-LEMG activity of CT muscle, lexical tone in Mandarin and vocal cord position and its impaction on vocal functions. 3. Detect the influence of lexical tone from conventional laryngoplasty for peripheral UVFP with eSLN injury.
Study designs: The current research is a two-year study. In the first year, the investigators will develop a standardized task for quantified LEMG analysis for CT muscles which were controlled by eSLN. In the second year, patients with acute UVFP will be enrolled into the study. By comprehensive evaluation including Q-LEMG analysis, the impact of injection laryngoplasty on tone adjustment can be identified. The results between UVFP with or without CT muscle damage will also be compared.
Predictive outcomes: 1. Developing a standard tool, Q-LEMG, to measure the function CT muscles. 2. Achieve the correlation of the neuromuscular control of lexical tone and CT muscle. 3. Analyze the impaction of early temporary injection on speech modal tone in Mandarin speakers and neuromuscular control in CT muscles. 4. Applying the data of tone and CT signals to future pitch controlled artificial electrolarynx animal models.
|Study Type :||Observational|
|Estimated Enrollment :||60 participants|
|Official Title:||The Function of Cricothyroid Muscle and Its Impaction on Mandarin Lexical Tones in Unilateral Vocal Fold Paralysis: a Quantified Laryngeal Electromyography Based Research|
|Study Start Date :||August 2013|
|Estimated Primary Completion Date :||July 2015|
|Estimated Study Completion Date :||December 2015|
unilateral recurrent laryngeal and superior laryngeal nerve paralysis
unilateral recurrent laryngeal nerve paralysis
- laryngeal electromyography [ Time Frame: before hyaluronate injection; one month after hyaluronate injection ]
- laboratory voice analysis [ Time Frame: before hyaluronate injection; one month after hyaluronate injection ]
The voice analysis:
fundamental frequency, Jitter (perturbation of frequency), Shimmer (perturbation of amplitude), harmonic-to-noise ratio (HN), and s/z ratio (SZ) .
- voice outcomes survey (VOS) [ Time Frame: before hyaluronate injection; one month after hyaluronate injection ]questionnaire
- Short form -36 [ Time Frame: before hyaluronate injection; one month after hyaluronate injection ]questionnaire
- voice range profile [ Time Frame: before hyaluronate injection; one month after hyaluronate injection ]The voice will be analyzed by computerized software. The extreme lowest and highest notes of frequencies production and the amplitude will be recorded and a voice map will be made as a plot of sound pressure level versus F0.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02184377
|Chang Gung Memorial Hospital|
|Principal Investigator:||Tuan-Jen Fang, MD||Chang Gung Memorial Hospital|