Altered Vestibular Perception and Transcranial Magnetic Stimulation
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ClinicalTrials.gov Identifier: NCT02184130
Recruitment Status :
(insufficient funds and participants, thus terminated)
The long-term goal of this research is to advance our knowledge of how information from the labyrinth is brought to perception and how adaptation to vestibular imbalance influences motion sensation. Patients with vestibular disorders frequently have disabling disturbances of perception. Related to these symptoms is that large areas of the cerebral hemispheres and the cerebellum receive information from the vestibular, visual and somatosensory systems that is integrated within a vestibular cortical network into an accurate perception of spatial orientation. Interrupting the pathways that process information about the direction of gravity and angular velocity leads to impairment of the internal estimate of gravity and the perception of body motion. The strategy of this research is to use repetitive transcranial magnetic stimulation (rTMS) to produce transient focal lesions that allow study of acute loss of function within the central vestibular pathways at the very beginning of adaptation. Our underlying hypothesis is that the immediate effects of a lesion in the cerebellum will be to affect ocular motor control of vestibular reflexes and perception alike but with a cortical lesion there will be dissociation between ocular motor control and perception. This research helps to understand the mechanisms involved in the perception of vestibular information and the cerebellar influence on processing vestibular input and offers a unique opportunity to make major inroads into the understanding and eventually treatment of the often incapacitating symptoms of patients with vestibular disease
Condition or disease
Verticality PerceptionSelf-motion Perception
Other: transcranial magnetic stimulation and motion stimuli
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 70 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
other neurological or systemic disorder which can cause dementia or cognitive dysfunction
prior history of a major psychiatric disorder
history of definite stroke
focal lesion on MRI exam
use of anxiolytic, antidepressant, neuroleptic or sedative medication
has MRI contraindication such as pacemaker, implanted pumps, shrapnel, etc. (full MRI screening form will be filled out).
History of seizure or a family history of epilepsy;
increased intracranial pressure, such as after infarctions or trauma
pregnancy or possibility of being pregnant unless precluded by a negative pregnancy test