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Trial record 29 of 1364 for:    transcranial magnetic stimulation

Altered Vestibular Perception and Transcranial Magnetic Stimulation

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ClinicalTrials.gov Identifier: NCT02184130
Recruitment Status : Terminated (insufficient funds and participants, thus terminated)
First Posted : July 9, 2014
Last Update Posted : July 2, 2018
Sponsor:
Information provided by (Responsible Party):
University of Zurich

Brief Summary:
The long-term goal of this research is to advance our knowledge of how information from the labyrinth is brought to perception and how adaptation to vestibular imbalance influences motion sensation. Patients with vestibular disorders frequently have disabling disturbances of perception. Related to these symptoms is that large areas of the cerebral hemispheres and the cerebellum receive information from the vestibular, visual and somatosensory systems that is integrated within a vestibular cortical network into an accurate perception of spatial orientation. Interrupting the pathways that process information about the direction of gravity and angular velocity leads to impairment of the internal estimate of gravity and the perception of body motion. The strategy of this research is to use repetitive transcranial magnetic stimulation (rTMS) to produce transient focal lesions that allow study of acute loss of function within the central vestibular pathways at the very beginning of adaptation. Our underlying hypothesis is that the immediate effects of a lesion in the cerebellum will be to affect ocular motor control of vestibular reflexes and perception alike but with a cortical lesion there will be dissociation between ocular motor control and perception. This research helps to understand the mechanisms involved in the perception of vestibular information and the cerebellar influence on processing vestibular input and offers a unique opportunity to make major inroads into the understanding and eventually treatment of the often incapacitating symptoms of patients with vestibular disease

Condition or disease Intervention/treatment Phase
Verticality Perception Self-motion Perception Other: transcranial magnetic stimulation and motion stimuli Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 7 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Altered Vestibular Perception by Virtual Lesions of Cerebral and Cerebellar Structures Using Repetitive Transcranial Magnetic Stimulation - Implications for Human Vestibular Dysfunction
Study Start Date : October 2011
Actual Primary Completion Date : November 2016
Actual Study Completion Date : September 2017

Arm Intervention/treatment
Experimental: TMS Other: transcranial magnetic stimulation and motion stimuli



Primary Outcome Measures :
  1. changes in verticality perception and self-motion perception after TMS (transcranial magnetic stimulation) [ Time Frame: within 30min after TMS ]

Secondary Outcome Measures :
  1. vestibulo-ocular reflex after TMS (transcranial magnetic stimulation) [ Time Frame: within 30min after TMS ]


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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  1. ages 18-70
  2. informed consent

Exclusion Criteria:

  1. disturbed consciousness
  2. other neurological or systemic disorder which can cause dementia or cognitive dysfunction
  3. prior history of a major psychiatric disorder
  4. history of definite stroke
  5. focal lesion on MRI exam
  6. use of anxiolytic, antidepressant, neuroleptic or sedative medication
  7. has MRI contraindication such as pacemaker, implanted pumps, shrapnel, etc. (full MRI screening form will be filled out).
  8. History of seizure or a family history of epilepsy;
  9. increased intracranial pressure, such as after infarctions or trauma
  10. pregnancy or possibility of being pregnant unless precluded by a negative pregnancy test
  11. history of any significant head trauma.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02184130


Locations
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Switzerland
University Hospital Zurich, Division of Neurology
Zurich, ZH, Switzerland, 8091
Sponsors and Collaborators
University of Zurich
Investigators
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Principal Investigator: Dominik Straumann, Prof MD University Hospital Zurich, Division of Neurology

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Responsible Party: University of Zurich
ClinicalTrials.gov Identifier: NCT02184130     History of Changes
Other Study ID Numbers: tms_percept_zurich
First Posted: July 9, 2014    Key Record Dates
Last Update Posted: July 2, 2018
Last Verified: June 2018