Effect of Transcutaneous Vagal Nerve Stimulation on Reducing Visually Induced Motion Sickness in Healthy Volunteers
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ClinicalTrials.gov Identifier: NCT02177890 |
Recruitment Status :
Completed
First Posted : June 30, 2014
Last Update Posted : December 2, 2015
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Condition or disease | Intervention/treatment | Phase |
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Visually Induced Motion Sickness in Healthy Volunteers | Device: Transcutaneous vagal nerve stimulation Device: Sham vagal nerve stimulation | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 25 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | Triple (Participant, Investigator, Outcomes Assessor) |
Primary Purpose: | Treatment |
Official Title: | Effect of Transcutaneous Vagal Nerve Stimulation on Reducing Visually Induced Motion Sickness in Healthy Volunteers |
Study Start Date : | November 2014 |
Actual Primary Completion Date : | November 2015 |
Actual Study Completion Date : | November 2015 |

Arm | Intervention/treatment |
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Experimental: Transcutaneous vagal nerve stimulation
Active vagal nerve stimulation to the left auricular branch of the vagus nerve
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Device: Transcutaneous vagal nerve stimulation
Other Name: NEMOS |
Placebo Comparator: Sham vagal nerve stimulation
Placebo vagal nerve stimulation - stimulator attached to the ear but rotated 180 degrees so that it is not stimulating the vagus nerve.
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Device: Sham vagal nerve stimulation |
- Reduction of the subjective sensation of nausea on a visual analogue scale [ Time Frame: 10 minutes ]
- Effect of transcutaneous vagal nerve stimulation on cardiac vagal tone [ Time Frame: 10 minutes ]
- Tolerability of transcutaneous vagal nerve stimulation [ Time Frame: 10 minutes ]

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Ages Eligible for Study: | 18 Years to 75 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Healthy subjects, aged 18-65, from staff, students and local population of Queen Mary, University of London.
- Inclusion will be determined on the basis of availability, with no prior selection bias included. They should be able to attend the Wingate Institute for at least 2 x 1 hour sessions.
- Subjects who score >15 on MSSQ (suggesting that they are sensitive to visually induced nausea).
Exclusion Criteria:
- Subjects unable to provide informed consent.
- Subjects with any systemic disease or medications that may influence the autonomic nervous system (e.g. beta-agonists or Parkinson's disease).
- Subjects who score <15 on MSSQ (suggesting that they are insensitive to visually induced nausea).
- Pregnant females to prevent any confounding effects on pregnancy related nausea.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02177890
United Kingdom | |
Wingate Institute of Neurogastroenterology | |
London, United Kingdom, E1 @AJ |
Principal Investigator: | Adam D Farmer, PhD MRCP | Wingate Institute |
Publications:
Responsible Party: | Adam Farmer, Research fellow, Wingate Institute of Neurogastroenterology |
ClinicalTrials.gov Identifier: | NCT02177890 |
Other Study ID Numbers: |
1-Farmer |
First Posted: | June 30, 2014 Key Record Dates |
Last Update Posted: | December 2, 2015 |
Last Verified: | November 2015 |
Motion Sickness |