Pharmacokinetic and Pharmacodynamic Effects of Oral Cannabis
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ClinicalTrials.gov Identifier: NCT02165176
Recruitment Status :
First Posted : June 17, 2014
Last Update Posted : October 21, 2015
Johns Hopkins University
Substance Abuse and Mental Health Services Administration (SAMHSA)
Few studies have been conducted to assess the pharmacokinetic and pharmacodynamic effects of orally consumed intact cannabis (e.g., cannabis-containing brownies). Careful analysis of oral cannabis dose effects on these parameters is required to determine the level and duration of biological cannabinoid exposure and associated subjective, cardiovascular and cognitive effects. The present study will evaluate the detection of cannabinoids in oral fluid, plasma, hair, and urine for up to 9 days following consumption of oral cannabis (10mg, 25mg, or 50mg THC). In addition, we will conduct subjective, behavioral, and cognitive performance assessments to evaluate the time course of the consequences of oral cannabis ingestion among study participants. The outcomes of the study will extend scientific knowledge about the behavioral pharmacology and toxicology of oral cannabis and can inform policies regarding clinical, workplace and roadside drug testing programs.
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Ages Eligible for Study:
18 Years to 45 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Have provided written informed consent
Be between the ages of 18 and 45
Be in good general health based on a physical examination, medical history, vital signs, 12-lead ECG and screening urine and blood tests
Test negative for recent cannabis use in urine at the screening visit (confirmed by GC/MS laboratory test) and at clinic admission
Test negative for other drugs of abuse, including alcohol at the screening visit and at clinic admission
Demonstrate ability to expectorate 3-5 mL of "native" oral fluid over a 5-minute period
Not be pregnant or nursing (if female). All females must have a negative serum pregnancy test at the screening visit and a negative urine pregnancy test at clinic admission.
Have a body mass index (BMI) in the range of 19 to 36 kg/m2
Have head hair that is at least 4 cm (approximately one and a half inches) in length on the back of the head.
Blood pressure at Screening Visit does not exceed a systolic blood pressure (SBP) of 150 mmHg or a diastolic blood pressure (DBP) of 90 mmHg
Have no allergies to any of the ingredients used to prepare cannabis brownies (chocolate, eggs, wheat, etc.).
Non-medical use of psychoactive drugs other than, nicotine, alcohol, or caffeine 3 month prior to the Screening Visit;
History of or current evidence of significant medical or psychiatric illness judged by the investigator to put the participant at greater risk of experiencing an adverse event due to exposure or completion of other study procedures.
Use of an OTC, systemic or topical drug(s), herbal supplement(s), or vitamin(s) within 14 days of experimental sessions; which, in the opinion of the investigator or sponsor, will interfere with the study result or the safety of the subject.
Use of a prescription medication (with the exception of birth control prescriptions) within 14 days of experimental sessions; which, in the opinion of the investigator or sponsor, will interfere with the study result or the safety of the subject.
Use of hemp seeds or hemp oil in any form in the past 3 months.
Use of dronabinol (Marinol) within the past 6 months.
History of xerostomia (dry mouth), or the presence of mucositis, gum infection or bleeding, or other significant oral cavity disease or disorder that in the investigator's opinion may affect the collection of oral fluid samples.
History of clinically significant cardiac arrhythmias or vasospastic disease (e.g., Prinzmetal's angina).
Abnormal EKG result that in the investigator's opinion is clinically significant.
Enrolled in another clinical trial or have received any drug as part of a research study within 30 days prior to dosing.