Salivary Cortisol Measurements by Mass Spectrometry
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Cortisol is a hormone critical for survival in times of stress. Currently most measurements are done with blood samples. The hypothesis of this study is cortisol measured from saliva using mass spectrometry can be used to replace measurements by blood.
Condition or disease
Cortisol levels change depending on the time of day. Salivary samples were collected from health controls at bedtime, midnight and first morning waking on two consecutive nights and salivary cortisol levels were measured using mass spectrometry. In a patients with possible endocrine disorders who were going through an adrenocortiotropin stimulation test for adrenal insufficiency, salivary cortisol was measured prior to giving cosyntropin and 30-40 minutes after cosyntropin.
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Layout table for eligibility information
Ages Eligible for Study:
3 Years to 17 Years (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients with possible endocrine disorders seen during outpatient pediatric endocrinology visit or inpatient consultations. Healthy controls were open to the general public in California.
Subjects with possible endocrine disorder
Tracheostomy or ventilator dependent
Gastrotomy tubed dependent or unable to eat/drink by mouth