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Emotional and Change-related Attention in Autism (AUTATTEN)

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ClinicalTrials.gov Identifier: NCT02160119
Recruitment Status : Unknown
Verified February 2015 by Institut National de la Santé Et de la Recherche Médicale, France.
Recruitment status was:  Recruiting
First Posted : June 10, 2014
Last Update Posted : February 6, 2015
Sponsor:
Information provided by (Responsible Party):
Institut National de la Santé Et de la Recherche Médicale, France

Brief Summary:
Several studies seem to indicate that emotional attention and change-related attention are impaired in ASD. The goal of this study is to identify the relationships between those two types of automatic attention in visual and auditory modalities in subjects with ASD compared to healthy controls and also, over the course of development (children, adults). In order to achieve this goal, the investigators will use complementary techniques (EEG and MRI-based techniques (fMRI, DTI)).

Condition or disease Intervention/treatment
Autism Spectrum Disorders Other: MRI-based techniques Other: EEG

Detailed Description:
Autism Spectrum Disorders (ASD) are characterized by major handicap in social interaction and in daily life adaptation. The orienting response towards potentially relevant events involves automatic attentional mechanisms that would be elicited mainly by two classes of biologically important stimulations: novel stimuli and emotional stimuli. The neural basis of emotional and change‐related attention in ASD will be explored by investigating brain reactivity in both visual and auditory modalities, during tasks mixing emotional and non emotional stimuli.

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Study Type : Observational
Estimated Enrollment : 140 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Emotional and Change-related Attention in Autism
Study Start Date : June 2014
Estimated Primary Completion Date : June 2017
Estimated Study Completion Date : June 2018

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
Healthy Controls Other: MRI-based techniques
fMRI, DTI
Other Names:
  • Functional magnetic resonance imaging
  • Diffusion Tensor Imaging

Other: EEG
ERP
Other Names:
  • Electroencephaolgraphy
  • Event-related potential (ERP)

Autism Spectrum Disorders Other: MRI-based techniques
fMRI, DTI
Other Names:
  • Functional magnetic resonance imaging
  • Diffusion Tensor Imaging

Other: EEG
ERP
Other Names:
  • Electroencephaolgraphy
  • Event-related potential (ERP)




Primary Outcome Measures :
  1. Neural responses to neutral and emotional stimuli [ Time Frame: 1 day ]
    ERP (Event-related potential), fMRI and DTI



Information from the National Library of Medicine

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Ages Eligible for Study:   5 Years to 45 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Children/ adults with ASD and healthy children/ adults
Criteria

Inclusion Criteria:

  • No past history of central nervous system disorders
  • Written consent
  • Affiliated to the National Health Insurance
  • Do not participate to another biomedical research
  • For ASD group: Children with autism spectrum disorder (DSM-V criteria) and adults with high-functioning autism
  • For healthy subjects: No past history of difficulties in early childhood for acquisition of walk, language or reading and no psychiatric disorders

Exclusion Criteria:

  • Abnormal corrected vision
  • Abnormal audition
  • Not stabilized psychoactive treatment or treatment that can modify electrogenesis
  • Infectious or metabolic diseases
  • Epilepsies
  • Impossibility to participate to the whole study
  • For subjects participating to the MRI recordings: MRI counter-indications (pace-makers ...), claustrophobia or a positive pregnancy test

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02160119


Locations
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France
University Hospital Recruiting
Tours, France, 37044
Contact: Marie GOMOT, PhD    +33247478664    gomot@univ-tours.fr   
Contact: Secretariat    +33247478412      
Principal Investigator: Frédérique BONNET-BRILHAULT, MD,PhD         
Sponsors and Collaborators
Institut National de la Santé Et de la Recherche Médicale, France
Investigators
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Principal Investigator: Frédérique BONNET-BRILHAULT, MD,PhD Institut National de la Santé Et de la Recherche Médicale, France

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Responsible Party: Institut National de la Santé Et de la Recherche Médicale, France
ClinicalTrials.gov Identifier: NCT02160119     History of Changes
Other Study ID Numbers: C13-26
2013-A01315-40 ( Registry Identifier: IDRCB )
First Posted: June 10, 2014    Key Record Dates
Last Update Posted: February 6, 2015
Last Verified: February 2015

Keywords provided by Institut National de la Santé Et de la Recherche Médicale, France:
Autism Spectrum Disorders
Emotion
Attention
Event-related potential
Functional neuroimaging
Diffusion Tensor Imaging
Development

Additional relevant MeSH terms:
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Autistic Disorder
Autism Spectrum Disorder
Child Development Disorders, Pervasive
Neurodevelopmental Disorders
Mental Disorders