Canadian Cohort on the Origin and Progression of Airway Disease: Physiology Platform
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02153684|
Recruitment Status : Suspended (Temporarily suspended due to COVID-19)
First Posted : June 3, 2014
Last Update Posted : September 17, 2020
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||120 participants|
|Official Title:||Canadian Cohort on the Origin and Progression of Airway Disease: Physiology Platform|
|Study Start Date :||March 2015|
|Estimated Primary Completion Date :||December 2020|
|Estimated Study Completion Date :||September 2022|
Mild COPD, symptomatic
Smokers fitting GOLD 1B criteria for COPD
Mild COPD, asymptomatic
Smokers fitting GOLD 1A criteria for COPD
Symptomatic smokers, at risk for COPD
Smokers who do not meet spirometric criteria for COPD
Healthy, non-smoking controls
Non-smokers, matched to smoking groups for age (>40 yrs of age) and gender
- Small airway function [ Time Frame: 1 day (Time of visit) ]There is no single measurement of small airway function since this study is evaluating which measurements, among a list of conventional and experimental physiological parameters, best characterize the nature and extent of impairment of respiratory function in the smoking study groups and which of these parameters best predict clinical outcome (i.e., dyspnea, exercise capacity, ventilatory capacity, health status). Assessments will include: spirometry, closing volume, impulse oscillometry, frequency dependence of dynamic lung compliance, plethysmographic lung volumes and metronome-paced dynamic hyperinflation.
- Cardiopulmonary exercise test [ Time Frame: 1 day (Time of visit) ]Includes measurements of exertional dyspnea (intensity and quality), peak exercise capacity (peak oxygen uptake [VO2]) and ventilatory responses (ventilation, pulmonary gas exchange, breathing pattern, operating lung volumes and tidal flow-volume loops) during symptom-limited incremental cardiopulmonary cycle exercise testing.
- Clinical outcome [ Time Frame: 1 day (Time of visit) ]Includes questionnaires regarding chronic activity-related dyspnea, respiratory symptoms, health status and physical activity.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02153684
|Canada, British Columbia|
|University of British Columbia|
|Vancouver, British Columbia, Canada, V6Z 1Y6|
|Queen's University and Kingston General Hospital|
|Kingston, Ontario, Canada, K7L 2V7|
|Montreal, Quebec, Canada, H2W 1S4|
|Principal Investigator:||Denis E O'Donnell, MD, FRCPC||Queen's University and Kingston General Hospital|