Training Effects on Fuel Metabolism (TrainMeUpMN)
|ClinicalTrials.gov Identifier: NCT02150889|
Recruitment Status : Active, not recruiting
First Posted : May 30, 2014
Last Update Posted : January 3, 2018
The investigators are interested in how skeletal muscle processes fat and how this may affect insulin resistance. This is an important question since insulin resistance predates and predicts type 2 diabetes. The investigators are especially interested in learning about the effects of weight and training on insulin resistance. The investigators will study people before and after supervised aerobic or yoga training to identify differences in resting fat and sugar metabolism which may lead to differences in insulin resistance. The investigators will test these differences using stable isotopes, and the use of these stable isotopes is experimental.
Overweight/Obese Group: Eight visits will be required at the University of Minnesota Clinical Research Unit. Four visits will be done before training (screen and 3 pre-training visits), 1 visit during the training, and 3 post-training visits will be done. In between, the training will take about 16 weeks and will be a supervised treadmill program.
Lean/Trained Group: Four visits will be required at the University of Minnesota Clinical Research Unit (screen and 3 study visits).
|Condition or disease||Intervention/treatment||Phase|
|Healthy Subjects Lean Trained Subjects Overweight and Obesity||Behavioral: Running Program Behavioral: Yoga Program||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||64 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Training Effects on Fuel Metabolism|
|Study Start Date :||July 2014|
|Estimated Primary Completion Date :||December 2018|
|Estimated Study Completion Date :||December 2018|
No Intervention: Lean Trained
Experimental: Obese or Overweight
Running Program Yoga Program
Behavioral: Running Program
16 week supervised running program
Behavioral: Yoga Program
once weekly supervised yoga
- Differences in insulin sensitivity between groups [ Time Frame: Before and after exercise program (exercise program will take 16 weeks, expected average for evaluation will be 20 weeks) ]Will use HOMA-IR and hyperinsulinemia-euglycemic clamp
- Differences in fitness level between groups [ Time Frame: before and after exercise program (exercise program will take 16 weeks, expected average for evaluation will be 20 weeks) ]we will measure fitness level by treadmill based VO2 max testing.
- Differences in body composition between groups [ Time Frame: before and after exercise program ((exercise program will take 16 weeks, expected average for evaluation will be 20 weeks) ]we will measure body composition by iDEXA to look at changes and total fat, visceral fat, and subcutaneously pre-and post exercise. This will be a noninvasive x-ray based measurement (x-ray exposure is extremely low and is equivalent to 1 day of natural radiation in Minnesota)
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02150889
|United States, Minnesota|
|University of Minnesota|
|Minneapolis, Minnesota, United States, 55455|
|Principal Investigator:||Lisa S. Chow, MD||University of Minnesota - Clinical and Translational Science Institute|